血清HE4、AMH、INHB在卵巢子宫内膜异位囊肿中的表达及意义

Expression and Significance of Serum HE4,AMH and INHB in Ovarian Endometriotic Cyst

目的探讨人附睾分泌蛋白E4(HE4)、抗苗勒氏管激素(AMH)、抑制素B(INHB)在卵巢子宫内膜异位囊肿中的表达及意义。方法选取2016年1月至2018年1月在我院治疗的卵巢子宫内膜异位囊肿患者42例(卵巢子宫内膜异位囊肿组)和卵巢单纯囊肿患者53例(卵巢单纯囊肿组),检测两组血清HE4、AMH、INHB水平。结果卵巢子宫内膜囊肿组HE4水平为(65.22±10.41) pmol/L,明显高于卵巢单纯囊肿组,差异有统计学意义(P<0.05),而AMH和INHB分别为(1.41±0.52) ng/m L和(24.41±2.80) pg/m L,明显低于卵巢单纯囊肿组,差异有统计学意义(P<0.05);Spearman秩相关分析显示AMH、INHB与患者年龄呈负相关(r=-0.435和-0.401,P<0.05);单双侧子宫内内膜异位囊肿患者HE4、AMH、INHB比较差异无统计学意义(P>0.05);血清HE4、AMH、INHB鉴别子宫内内膜异位囊肿的ROC曲线下面积分别为0.776、0.926和0.867(P<0.05)。结论血清HE4、AMH、INHB在卵巢子宫内膜异位囊肿鉴别诊断中有一定应用价值,同时AMH和INHB与患者年龄相关,与单双侧受累无明显关系。

Objective To investigate the expression and significance of human epididymis secretory proteins E4(HE4),anti-Mullerian hormone(AMH)and inhibin B(INHB)in ovarian endometriotic cyst.Methods 42 patients with ovarian endometriosis cyst(ovarian endometriosis cyst group)and 53 patients with simple ovarian cyst(ovarian cyst group)were enrolled in our hospital from January 2016 to January 2018.Serum levels of HE4,AMH,and INHB were measured in the both groups.Results Level of HE4 in ovarian endometrial cyst group was(65.22±10.41)pmol/L,which was significantly higher than that in the simple ovarian cyst group,and the difference was statistically significant(P<0.05),while levels of AMH and INHB were(1.41±0.52)ng/mL and(24.41±2.80)pg/mL,respectively,which were significantly lower than those in the simple ovarian cyst group,and the difference was statistically significant(P<0.05).Spearman rank correlation analysis showed that levels of AMH and INHB were negatively correlated with patient age(r =-0.435和-0.401, P<0.05).There was no significant difference in levels of HE4,AMH and INHB between patients with single and bilateral endometriotic cyst(P>0.05);The areas under the ROC curve of serum HE4,AMH,INHB to identify endometriotic cyst were 0.776,0.926,and 0.867,respectively(P<0.05).Conclusion Serum HE4,AMH and INHB have certain application value in the differential diagnosis of ovarian endometriotic cyst.AMH and INHB are related to age of patients,but no obvious relationship with single or bilateral involvement.