沙丁胺醇联合布地奈德雾化吸入治疗COPD急性发作的临床研究

Clinical study of salbutamol combined with budesonide atomized inhalation in the treatment of acute attack of COPD

目的探讨沙丁胺醇联合布地奈德雾化吸入治疗慢性阻塞性肺病急性发作患者的临床疗效.方法将我院2017年6月~2018年6月收治的193例患者随机分为观察组(n=97)和对照组(n=96).对照组在常规基础上给予沙丁胺醇雾化吸入治疗,观察组在对照组的基础上给予沙丁胺醇联合布地奈德雾化吸入治疗.观察比较两组临床疗效、肺功能指标变化、IL-13、IL-35水平情况、症状消失时间及住院时间.结果观察组整体疗效明显优于对照组(P<0.01);总有效率86.60%(84/97)高于对照组的72.92%(70/96)(P<0.05).治疗后,两组FEV1、FEV1%及FEV]FVC均高于治疗前(P<0.01),且观察组高于对照组(P<0.01).两组IL-13低于治疗前,IL-35高于治疗前(P<0.05);且观察组IL-13低于对照组,IL-35高于对照组(P<0.05).观察组症状消失时间和住院时间均低于对照组(P<0.01).结论沙丁胺醇联合布地奈德雾化吸入治疗慢性阻塞性肺病急性发作临床疗效显著,可有效改善患者肺功能,缩短住院时间及症状缓解时间.

Objective To investigate the clinical efficacy of salbutamol combined with budesonide atomized inhalation in the treatment of patients with acute attack of chronic obstructive pulmonary disease (COPD). Methods A total of 193 patients who were admitted to our hospital from June 2017 to June 2018 were selected and randomly divided into observation group (n=97) and control group (n=96). The control group was given salbutamol atomized inhalation on the basis of the conventional basic treatment. The observation group was given salbutamol combined with budesonide atomized inhalation on the basis of the control group. The clinical efficacy, changes of lung function index, levels of IL-13, IL-35, time of symptom disappearance and length of stay were observed and compared between the two groups. Results The overall efficacy in the observation group was significantly better than that in the control group (P<0.01);the total effective rate of 86.60%(84/97) in the observation group was higher than 72.92%(70/96) in 70 cases in the control group (P<0.05). After treatment, FEV1, FEV1% and FEV1/FVC were higher than those before treatment in both groups (P<0.01), and the observation group was higher than the control group(P<0.01). The levels of IL-13 were lower than those before treatment in both groups, and IL-35 was higher than that before treatment(P<0.05);the IL-13 in the observation group was lower than that in the control group, and IL-35 was higher than that in the control group(P<0.05). The symptom disappearance time and length of stay in the observation group were lower than those in the control group (P<0.01). Conclusion Salbutamol combined with budesonide atomized inhalation in the treatment of acute attack of chronic obstructive pulmonary disease is clinically effective, which can effectively improve the lung function of patients, shorten the length of hospital stay and the symptom disappearance time.