焦虑症状对抑郁障碍患者睡眠影响的研究

Effects of Anxiety Symptoms on Sleep in Patients with Depressive Disorder

目的:探究焦虑症状对抑郁障碍患者睡眠的影响。方法:随机选取在滇中地区(多中心)诊治的单纯抑郁障碍患者及伴有焦虑症状的抑郁障碍患者各48例作为研究对象,对照组为单纯抑郁组,观察组为伴有焦虑症状的抑郁组。通过对2组患者的汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、临床总体印象量表(CGI)、睡眠相关性日间损害评估表(PROMIS)、匹茨堡睡眠质量指数量表(PSQI)评分比较,评估焦虑症状对抑郁障碍患者睡眠的影响。结果:2组抑郁障碍患者的HAMD及CGI评分差异无统计学意义(P> 0. 05)。观察组的HAMA、PROMIS、PSQI 3项评分指标均高于对照组差异有统计学意义(P <0. 01);观察组在主观睡眠质量、睡眠持续性、睡眠紊乱、使用催眠药物、日间功能障碍5个因子的得分均较对照组高,差异有统计学意义(P <0. 01)。结论:伴有焦虑症状的抑郁障碍患者失眠发生率及失眠严重程度更高;其中在主观睡眠质量、睡眠持续性、睡眠紊乱、使用催眠药物、日间功能障碍5个方面较为明显。

Objective: To investigate the effects of anxiety symptoms on sleep in patients with depressive disorder. Methods: A total of 48 patients with simple depressive disorder and 48 patients with anxiety disorder were randomly selected for the study.The control group was simple depressive group and the observation group was depressed group with anxiety symptoms.Through the Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA),Clinical General Impression Scale(CGI),Sleep Related Day Damage Assessment Scale(PROMIS),and Pittsburg Sleep Quality Index Scale(PSQI)score comparison between the two groups of patients,Assess the effects of anxiety symptoms on sleep in patients with depressive disorder. Results: There was no significant difference in HAMD and CGI scores between the two groups of patients with depressive disorder( P >0.05),and the three score indicators of HAMA,PROMIS,and PQI in the observation group were higher than the control group( P <0.01);The group scored higher than the control group in five factors:subjective sleep quality,sleep continuity,sleep disorder,hypnotic drug use,and daytime dysfunction( P <0.01). Conclusion: The incidence of insomnia and Yanzhongchengdu were higher in patients with depressive disorder with anxiety symptoms.Among them,subjective sleep quality,sleep continuity,sleep disorders,use of hypnotic drugs,and daytime dysfunction were more obvious.