血清心肌营养因子-1、细胞间黏附因子-1水平检测在老年急性心肌梗死患者中的应用价值

The value of serum cardiotrophin-1 and intercelluar adhesion molecule-1 in elderly patients with acute myocardial infarction

目的分析血清心肌营养因子-1(CT-1)、细胞间黏附因子-1(ICAM-1)水平检测在老年急性心肌梗死(AMI)患者中的应用价值。方法将2017年9月至2018年10月于胶州市人民医院就诊的84例老年AMI患者纳入观察组,其中42例非ST段抬高心肌梗死(NSTEMI)患者纳入NSTEMI组,42例ST段抬高心肌梗死(STEMI)患者纳入STEMI组,将同期胶州市人民医院45例体检健康者纳入对照组。检测受试者血清CT-1、ICAM-1水平。比较3组受试者血清CT-1、ICAM-1水平和不同预后患者血清CT-1、ICAM-1水平。结果 3组受试者血清CT-1、ICAM-1水平相比,差异有统计学意义(均P<0.05)。NSTEMI患者血清CT-1、ICAM-1水平高于对照组患者,STEMI患者血清CT-1、ICAM-1水平高于NSTEMI患者和对照组患者,差异有统计学意义(均P<0.05)。存活患者血清CT-1、ICAM-1水平均较死亡患者低,差异有统计学意义(均P<0.05)。结论血清CT-1、ICAM-1水平与老年AMI患者病情严重程度有关,可作为临床判断预后的重要指标。

Objective To analyze the value of serum cardiotrophin-1(CT-1) and intercelluar adhesion molecule-1(ICAM-1) in elderly patients with acute myocardial infarction(AMI). Methods Eighty-four elderly patients with AMI who were treated in Jiaozhou People’s Hospital from September 2017 to October 2018 were enrolled in observation group. Among them, 42 patients with non-ST segment elevation myocardial infarction(NSTEMI) were enrolled in NSTEMI group, 42 patients with ST segment elevation myocardial infarction(STEMI) were included in STEMI group. Forty-five healthy people underwent medical examination in Jiaozhou People’s Hospital at the same period were enrolled in control group. Serum CT-1 and ICAM-1 levels were measured in the subjects. Serum CT-1 and ICAM-1 levels were compared between the three groups. Serum CT-1 and ICAM-1 levels were compared between patients with different prognosis.Results The levels of serum CT-1 and ICAM-1 in the 3 groups were significantly different(both P<0.05). The levels of serum CT-1 and ICAM-1 in NSTEMI group were higher than those in control group, and the levels of serum CT-1 and ICAM-1 in STEMI group were higher than those in NSTEMI proup and control group(all P<0.05). The serum levels of CT-1 and ICAM-1 in surviving patients were lower than those in the dead patients, and the differences were statistically significant(both P<0.05).Conclusion The levels of serum CT-1 and ICAM-1 are related to the severity of AMI patients. They could be used as important indicators for clinical prognosis.