泮托拉唑钠联合替格瑞洛在急性心肌梗死并消化道出血患者中的应用

Application of pantoprazole sodium combined with ticagrelor in patients with acute myocardial infarction complicated with gastrointestinal bleeding

目的分析泮托拉唑钠联合替格瑞洛在急性心肌梗死(AMI)并消化道出血(GIB)患者中的应用效果。方法选取2017年6月至2018年10月河南省人民医院收治的52例AMI并GIB患者,按随机数表法分为对照组(26例)与观察组(26例)。对照组接受替格瑞洛治疗,观察组接受泮托拉唑钠+替格瑞洛治疗。观察对比两组治疗效果、不良反应发生率及治疗前后前列腺素E2(PGE2)水平变化情况。结果对照组总有效率为61.54%(16/26),观察组总有效率为88.46%(23/26)。观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗7 d后,两组血清PGE2水平均较治疗前提高,且观察组血清PGE2水平高于对照组(P<0.05)。对照组不良反应发生率为19.23%(5/26),观察组不良反应发生率为11.54%(3/26)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论泮托拉唑钠联合替格瑞洛治疗AMI并GIB患者疗效显著,可有效提高PGE2水平,安全性较高。

Objective To analyze the effect of pantoprazole sodium combined with ticagrelor in patients with acute myocardial infarction(AMI) complicated with gastrointestinal bleeding(GIB).Methods A total of 52 patients with AMI and GIB in Henan Provincial People’s Hospital from June 2017 to October 2018 were enrolled and divided into control group(26 cases) and observation group(26 cases) by random number table method. The control group was treated with ticagrelor, and the observation group was treated with pantoprazole sodium and ticagrelor. The therapeutic effects, the incidence of adverse reactions, and prostaglandin E2(PGE2) levels before and after treatment were compared between the two groups.Results The total effective rate was 61.54%(16/26) in the control group and 88.46%(23/26) in the observation group. The total effective rate of the observation group was higher than that of the control group(P<0.05). After 7 days of treatment, the levels of serum PGE2 in both groups were higher than those before treatment, and the level of serum PGE2 in the observation group was higher than that in the control group(P<0.05). The incidence of adverse reactions was 19.23%(5/26) in the control group and 11.54%(3/26) in the observation group. There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Pantoprazole sodium combined with ticagrelor in the treatment of AMI and GIB patients has significant curative effect, which can effectively improve the level of PGE2 with higher safety.