N2O滥用及法医学鉴定

N2O abuse and its Forensic identification

N2O滥用情况普遍,已逐渐蔓延至国内娱乐场所。N2O滥用会使维生素B12失去活性,引起维生素B12缺乏症并导致外周神经损害等临床症状。同时N2O作为NMDA受体非竞争性拮抗剂,会引起行为怪异、迷失方向等精神异常症状。高浓度N2O会引起缺氧导致意外窒息死亡,毒化检测需要新鲜收集、密封保存的生物检材。

N2O abuse is widespread and has gradually spreaded to domestic entertainment venues.N2O abuse inactivates vitamin B12, resulting in a functional vitamin B12 deficiency and initially causing clinical symptoms such as peripheral nerve damage. As a non-competitive NMDA receptor antagonist, N2O abuse will cause a series of psychiatric disorders such as bizarre paranoid behavior and disorientation. Cases of hypoxia and fatal accidental asphyxia had been reported due to high concentration of N2O abuse. Post-mortem specimens should be fresh and sealed for N2O measurement.