婴幼儿肠道菌群的定植与演替

The colonization and succession of infant gut microbiota

婴幼儿的肠道内栖息着数量巨大的微生物,其中占据主导地位的是细菌,其在维持内环境稳态、调节能量代谢等方面发挥着复杂的作用。婴幼儿肠道细菌的定植起始于子宫内阶段,在围产期及出生后的相当一段时间内,其组成结构会受到各种因素的影响,如孕周、分娩方式、母乳的喂养等。现总结近期关于婴幼儿肠道菌群的相关研究进展,并探讨其在婴幼儿肠道的定植过程及影响其演替的相关因素。

Great amounts of microorganisms inhabit in infant gut,the majority of which is bacteria with an indispensable but complicated role in maintaining internal environmental homeostasis,regulating energy metabolism and other health promotion activities.When the colonization begins in utero,it will be affected by various factors including gestational age,delivery mode,feeding pattern during prenatal to perinatal to postnatal life.This review aims to make a summary of recent studies about infant gut microbiota and discuss the microbiota colonization and relevant factors.