稳态磁场下秀丽隐杆线虫的生物学效应

Biological effects of static magnetic fields on Caenorhabditis elegans

随着家用电器的普及和磁场在现代医学的广泛应用,人类暴露于磁场的风险逐渐增大,磁场对人类健康与生态环境的影响已引起公众的日益关注。稳态磁场(static magnetic fields,SMFs)具有磁场强度及方向不随时间而发生变化的特性,而各种强度的稳态磁场实验装置陆续建成,为相关磁场生物学效应研究提供了重要实验平台。秀丽隐杆线虫(Caenorhabditis elegans)是一种应用广泛的模式生物,能灵敏感知磁场变化。本文结合近年来国内外稳态磁场装置的发展相关研究进展,综述了不同强度的稳态磁场对于秀丽隐杆线虫的生物学效应,主要涉及生长发育、老化、运动行为、应激和代谢等,以及其响应机制,并总结归纳了不同强度稳态磁场条件下秀丽隐杆线虫的生物磁效应的异同点,以期为稳态磁场的医疗应用以及各种暴露限量标准的制定提供理论参考。

With the popularity of household appliances and the wide application of magnetic fields in modern medicine,the risk of human exposure to magnetic fields has gradually increased.The influence of magnetic fields on human health and the ecological environment has attracted increasing public concern.Static magnetic fields (SMFs) are defined as the constant fields,which do not change in intensity or direction over time, while the development of magnetic facilities provides an important platform for the investigation of related biological effects.Caenorhabditis elegans is a widely used in vivo model and sensitive to magnetic field exposure.This paper reviews the biological effects of SMFs with different intensities on C.elegans,including growth,aging,locomotion behavior,stress and metabolism.The similarities and differences of the biological effects induced by different SMFs conditions are summarized,which will provide a theoretical reference for the medical application of SMFs and the establishment of exposure limit standards.