磁场对免疫细胞的生物学效应与作用机制

Biological effects and related mechanisms of magnetic fields on immune cells

磁场作为重要的物理因素是如何影响生物体的,而生物体又是如何响应磁场并产生广泛的生物学效应的,这是学术界关注多年的基本科学问题之一。近几年来,随着磁感应蛋白的发现,磁生物学成为国际前沿热点研究,并由此将引发一系列基于磁感应机制的由磁场来操控生物大分子乃至细胞行为、动物行为的各种应用。免疫细胞已被报道能够响应磁场并在磁场作用下改变细胞行为,但其作用机制并不十分清楚。该综述将简要介绍磁场对免疫细胞的生物学效应,并对磁感应机制研究现状进行总结和分析。深入了解磁场对免疫细胞的生物学效应和可能机制,一方面将有可能在细胞水平发现磁感应机制的新线索,另一方面有可能发掘用物理的手段来改变免疫细胞行为的新方法,探索新的免疫治疗途径。

How the physical factor magnetic fields influence biological systems and how biological systems respond to magnetic fields is a long-time interesting question.In recent years,with the discovery of magnetoreceptor mechanisms in animals,it materialized the novel applications of controlling cell and animal behaviors using magnetic fields.Immune cells have shown to response to magnetic fields,but the related mechanisms are largely unknown.Here we will introduce the biological effects of magnetic fields on immune cells,and summarize the recent status of magnetoreception mechanisms.With the deepen understanding of biological effects and related mechanisms of magnetic fields on immune cells,we will find new clues of cellular magnetoreception mechanisms,and will also explore new physical methods of controlling behaviors of immune cells and develop new methods of immune therapy.