SDC1及其相关蛋白RSPO1、WNT1、p16、WT1的表达对乳腺浸润性导管癌的预后价值分析

Prognostic value of SDC1 and the expression of RSPO1,WNT1,p16,WT1 for invasive ductal carcinoma of breast

目的:探讨SDC1及相关蛋白在乳腺浸润性导管癌组织中的表达与预后的关系。方法:运用免疫组织化学分析法检测80例乳腺浸润性导管癌患者癌组织中SDC1及其相关蛋白的表达,分析其与临床病理特征的关系。结果:SDC1阳性表达率在雌激素受体阴性表达组显著高于雌激素受体阳性表达组(P=0.033),WT1阳性表达率与肿瘤分期差异具有统计学意义(P=0.024),RSPO1阳性表达率在孕酮受体阳性组显著高于孕酮受体阴性表达组(P=0.015);RSPO1、WT1、p16的阳性表达与无瘤生存率显著相关(P<0.05),且其阳性表达时无瘤生存率较高;RSPO1、p16是影响无瘤生存率的因素,差异有统计学意义(P<0.05);SDC1的阳性表达与WNT1、WT1、p16的阳性表达呈显著正相关(r s>0,P<0.05)。结论:RSPO1和p16蛋白的表达水平可以作为乳腺癌浸润性导管癌的独立预后指标;SDC1与WNT1、WT1、p16在乳腺浸润性导管癌中的表达呈显著正相关。

Objective:To investigate the expression of SDC1 in the tissues of invasive ductal carcinoma of breast and its association with prognosis.Methods:The expression of SDC1,WNT1,WT1,RSPO1 and p16 among 80 invasive ductal carcinoma of breast cases were detected by immunohistochemical method,to explore its association with clinical pathological characteristics.Results:Higher positive expression rate of SDC1 was shown among women who had negative expression of estrogen receptors than those with positive expression of estrogen receptors(P=0.033).The positive expression rate of WT1 was associated with tumor grade(P=0.024),and higher expression rate of RSPO1 was found in women with positive progesterone receptors than those with negative progesterone receptors(P=0.015).The positive expression rate of RSPO1,WT1 and p16 were significantly associated with longer disease-free survival(P<0.05),especially for RSPO1 and p16(P<0.05).Expression of SDC1 were positively associated with WNT1,WT1 and p16(r s>0,P<0.05).Conclusion:Expression of RSPO1 and p16 could be the independent prognostic indicators of invasive ductal cancer of breast.Expression of SDC1were positively associated with the expression of WNT1,WT1,p16.