成人早期前体T急性淋巴细胞白血病(ETP-ALL)与非ETP-ALL的临床特点对比

Clinical characteristics comparative of adult early T-cell precursor and non-early T-cell precursor acute lymphoblastic leukemia

目的:对比分析成人早期前体T急性淋巴细胞白血病(ETP-ALL)与非早期前体T急性淋巴细胞白血病(non-ETP-ALL)的临床特点。方法:回顾性分析于我科系统诊治的成人T细胞急性淋巴细胞白血病(T-ALL)患者19例,其中ETP-ALL 6例,non-ETP-ALL 13例,对比两组患者临床基本状况、血液及骨髓检测结果、免疫分型结果及诱导治疗后缓解情况。结果:ETP-ALL组患者白细胞水平显著低于non-ETP-ALL组患者,血小板水平显著高于non-ETP-AL组患者,主要见于pro-T-ALL,首次诱导治疗后完全缓解或接近完全缓解(CR/CRi)率显著低于后者。结论:ETP-ALL患者具有较独特的临床特点,对常规诱导治疗反应差,有必要积极探索新的治疗方法和药物。

Objective:To investigate the clinical characteristics of adult early T-cell precursor(ETP)and non-early T-cell precursor(non-ETP)acute lymphoblastic leukemia(ALL).Methods:Clinical datas including basic clinical status,blood and bone marrow examination results,immunophenotyping results and remission status after induction therapy were compared between 6 patients with ETP-ALL and 13 cases with non-ETP-ALL who were diagnosed and treated systematically in our department.Results:Leukocyte count in ETP-ALL group was significantly lower than that in non-ETP-ALL group and platelet count was significantly higher than that in non-ETP-ALL group.Most ETP-ALL patients belong to pro-T-ALL by EGIL classification standards.CR/CRi rate after first course of induction therapy was significantly lower in ETP-ALL patients.Conclusion:ETP-T-ALL patients have unique clinical characteristics and poor response to conventional induction therapy,so it is necessary to explore new treatment methods.