摘要
鼻咽癌是一种发生于鼻咽部黏膜上皮的恶性肿瘤,以我国南方及东南亚地区最为常见。研究证实EB病毒(Epstein-Barr virus,EBV)感染与鼻咽癌的发生发展密切相关,并且EB病毒DNA(Epstein-Barr virus DNA,EBV-DNA)定量水平在鼻咽癌疾病进程、治疗及转归的过程中均会发生相应的规律性改变。因此,EBV-DNA检测在鼻咽癌筛查、早期诊断、个体化治疗及预后评估等方面具有较大的价值。本文就EBV-DNA检测在鼻咽癌中的应用价值及研究进展作简要综述。
Nasopharyngeal carcinoma(NPC)is a epithelial malignancy with uneven worldwide distribution and high prevalence in southern China and Southeast Asia.Studies have shown that Epstein-Barr virus(EBV)infection is closely related to the occurrence and development of nasopharyngeal carcinoma,and the quantitative level of EBV-DNA will change regularly during the disease progression,treatment and prognosis.Therefore,EBV-DNA detection is of great value in early diagnosis,screening,diagnosis of tumor recurrence or distant metastasis,prognosis,and individualized treatment for patients with nasopharyngeal carcinoma.The application and research progress of EBV-DNA detection in nasopharyngeal carcinoma are reviewed.
作者
周睿
朱婧
张涛
Zhou Rui;Zhu Jing;Zhang Tao(Department of Oncology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China.)
出处
《现代肿瘤医学》
CAS
2019年第21期3902-3905,共4页
Journal of Modern Oncology
基金
国家自然科学基金资助项目(编号:81803569)
重庆市卫生和计划生育委员会医学科研计划资助项目(编号:2017MSXM005)
关键词
鼻咽癌
EB病毒DNA检测
筛查
诊断
治疗
预后
nasopharyngeal carcinoma
Epstein-Barr virus DNA detection
screening
diagnosis
treatment
prognosis
