炎性肌纤维母细胞瘤诊断和治疗的研究进展

The progression of inflammatory myofibroblastic tumor in the diagnosis and treatment

炎性肌纤维母细胞瘤是近几年逐渐被认识和命名的肿瘤,该肿瘤可发生于全身各处,表现为单发或多发肿物,伴有发热、胸痛、咳嗽咳痰、乏力、消瘦等全身症状。肿瘤局部生长,可侵犯周围血管,可复发,在影像学上形似恶性肿瘤,镜下显示不同数量的肌纤维母细胞伴炎细胞不同程度的浸润。肿瘤的病因尚不清楚,现已证实肿瘤内ALK基因重排以及表达增多。本文针对该病的认识过程、遗传学、影像学、病理学及治疗预后作一综述。

Inflammatory myofibroblastic tumor has been a gradually knowing and named tumor in recent years.This tumor may occur in any place in human body,and there may be single or multiple lesions,combining with fever,chest pain,cough and expectoration,and other systemic symptoms like weakness and emaciation.When tumor grows in certain part,vascular invasion may happen at blood vessels around the tumor.IMT looks like the malignant tumor in iconography,and it shows different amounts of myofibroblast with inflammatory cells under the microscope.It is still not clear about the etiology of IMT,but it has been confirmed that this tumor ALK gene is getting rearranged and gene expression is increasing.This article reviewed and summarized the process of knowing IMT,and its genetics,imaging,pathology and prognosis for treatment.