甘露醇联合丙种球蛋白对重症手足口病患儿的疗效观察及白细胞计数CRP的影响

Effect of Mannitol combined with Gamma Globulin on Leukocyte count and CRP in Children with Severe Hand-foot-mouth Disease

目的:研究甘露醇联合丙种球蛋白对重症手足口病患儿的疗效观察及白细胞计数、C反应蛋白(CRP)的影响。方法:选取2014年2月至2018年2月的98例手足口病患儿。按照简单随机分组法将患儿分为观察组(n=51)和对照组(n=47),对照组采用丙种球蛋白治疗,观察组采用甘露醇联合丙种球蛋白治疗。观察两组治疗疗效情况,临床症状消退时间,白细胞计数、CRP水平,不良反应发生率。结果:治疗后,观察组总有效率显著高于对照组[94.11%(48/51)vs74.46%(35/47)](P<0.05);临床症状消退时间显著低于对照组[(2.18±0.63)dvs(4.01±0.85)d,(2.41±0.65)dvs(5.24±1.23)d,(2.90±0.52)dvs(5.86±1.30)d](P<0.05);白细胞计数、CRP显著低于对照组[(10.36±4.62)109/Lvs(10.64±5.09)109/L,(1.23±0.34)mg/Lvs(2.97±0.75)mg/L](P<0.05);不良反应总发生率显著低于对照组[5.88%(3/51)vs21.27%(10/47)](P<0.05)。结论:甘露醇联合丙种球蛋白治疗重症手足口病患儿疗效显著,可有效改善患儿的临床症状,降低白细胞计数、CRP的水平,安全可靠。

Objective: To study the curative effect of mannitol combined with gamma globulin on children with severe hand,foot and mouth disease and the influence of white blood cell count and C reactive protein (CRP). Methodss: 98 cases of hand,foot and mouth disease from February 2014 to February 2018 were selected. According to simple random grouping method,the children were divided into observation group (n=51) and control group (n=47). The control group was treated with gamma globulin,while the observation group was treated with mannitol combined with gamma globulin. The curative effect,clinical symptom subsidence time,white blood cell count,CRP level and the incidence of adverse reactions of the two groups were observed. Results: After treatment,the total effective rate of the observation group was significantly higher than that of the control group [94.11%(48/51) vs 74.46%(35/47)](P<0.05),and the time of clinical symptoms subsidence was significantly lower than that of the control group [(2.18±0.63) D vs (4.01±0.85) d,(2.41 (+0.65) D vs (5.24 ±1.23) d,(2.90±0.52) D vs (5.86±1.30) d](P < 0.05). The number and CRP were significantly lower than those of the control group [(10.36±4.62) 10 9/L vs (10.64±5.09) 10 9/L,(1.23±0.34) mg/L vs (2.97±0.75) mg/L](P < 0.05),and the total incidence of adverse reactions was significantly lower than that of the control group [(5.88%(3/51) vs 21.27%(10/47)](P<0.05). Conclusion: Mannitol combined with gamma globulin in the treatment of children with severe hand,foot and mouth disease has a significant effect. It can effectively improve the clinical symptoms of children with severe hand,foot and mouth disease,reduce the level of white blood cell count and CRP,and is safe and reliable.