芪苈强心胶囊联合贝那普利对老年高血压伴心力衰竭的疗效及神经内分泌激素的作用分析

Curative efficacy of Qili Qiangxin Capsule Combined with Benazepril in Treatment of Senile Hypertension Complicated with Heart Failure and Regulation Effects on of Neuroendocrine Hormones

目的:探讨芪苈强心胶囊联合贝那普利对老年高血压伴心力衰竭的疗效及神经内分泌激素的作用。方法:选择2016年1月至2018年9月我院接诊的104例高血压伴心力衰竭患者进行研究,通过简单随机数表法分为观察组54例和对照组50例,在常规治疗基础上,对照组给予贝那普利治疗,观察组联合芪苈强心胶囊治疗,均连续治疗8周。比较两组临床疗效、血清神经内分泌激素、血压、心功能及不良反应。结果:治疗后,观察组临床疗效总有效率明显比对照组高(P<0.05);两组血清血管紧张素(AngⅡ)、内皮素-1(ET-1)、去甲肾上腺素(NE)、收缩压(SBP)舒张压(DBP)、左室射血分数(LVEF)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)、6min步行距离(6MWT)在组间、不同时间点、组间·不同时间点的交互作用差异有统计学意义(P<0.05);两组治疗期间均未出现明显不良反应。结论:芪苈强心胶囊联合贝那普利治疗老年高血压伴心力衰竭效果显著,可有效调节血清神经内分泌激素表达,降低血压,改善心功能,且未增加药物不良反应,临床应用价值高。

Objective: To study the curative efficacy of Qili Qiangxin Capsule combined with Benazepril in treatment of senile hypertension complicated with heart failure and regulation effects on of neuroendocrine hormones. Methods: 104 patients of senile hypertension complicated with heart failure who received therapy from January 2016 to September 2018 in our hospital were selected as research objects,according to simple random number table method,those patients were divided into 54 case of the observation group and the 50 cases of the control group,on the basis of routine treatment,the control group was treated with benazepril,while the observation group was combined with Qili Qiangxin Capsule on the basis of the control group,they were treated for 8 weeks. The clinical efficacy,serum neuroendocrine hormones,blood pressure,cardiac function and adverse reactions were compared between the two groups. Results: After treatment,the total effective rate in the observation group was significantly higher than those in the control group(P<0.05);there were significant differences in the interaction of serum angiotensin Ⅱ(AngⅡ),endothelin-1 (ET-1),norepinephrine (NE),systolic blood pressure (SBP),diastolic blood pressure (DBP),left ventricular ejection fraction (LVEF),left ventricular end-systolic diameter (LVESD),left ventricular end-diastolic diameter (LVEDD),6-minute walking distance (6MWT) between groups at interblock,different time points,interblock·different time points(P<0.05);there were no obvious adverse reactions during treatment in both groups. Conclusion: Qili Qiangxin Capsule combined with Benazepril is well for senile hypertension complicated with heart failure,which can effectively regulate the expression of serum neuroendocrine hormones,reduce blood pressure,improve cardiac function,and no increase in adverse drug reactions the clinical application value is high.