CRP联合SAA在小儿细菌性肺炎与支原体肺炎鉴别诊断中的应用价值

Value of CRP combined with SAA in differential diagnosis of bacterial pneumonia and Mycoplasma pneumonia in Children

目的:分析探讨CRP联合SAA在小儿细菌性肺炎与支原体肺炎鉴别诊断中的应用价值。方法:选取我院于2016年12月至2018年12月期间收治的100例因肺部感染住院的患儿,根据其感染情况将其划分为甲乙两组,其中甲组患儿均为支原体感染患儿,共75例,乙组患儿为细菌感染患儿,共25例;选取同期来我院体检的健康儿童20例作为对照组。测定三组儿童的C反应蛋白水平和血清淀粉样蛋白A水平,并且采用ROC曲线对其进行分析。结果:对照组儿童的CRP水平和SAA水平显著低于甲、乙两组患儿,甲组患儿的CRP水平和SAA水平均显著低于乙组患儿(均P<0.05);三组入选儿童之间的SAA/CRP比值均无明显差异(均P>0.05)。SAA检测对于细菌性感染和支原体感染的儿童肺炎诊断准确性均较高,CRP检测仅对细菌性感染的儿童肺炎诊断准确性较高,对于支原体感染的儿童肺炎鉴别诊断意义较小。结论:在诊断儿童细菌性感染方面CRP检测和SAA检测均具有较高的准确性,并且在儿童肺炎支原体感染的诊断及鉴别诊断中SAA检测同样具有较高的应用价值,值得在临床上加以推广运用。

Objective: To analyze the value of CRP combined with SAA in the differential diagnosis of bacterial pneumonia and mycoplasma pneumonia in children. Methods::From December 2016 to December 2018,100 cases of children hospitalized due to pulmonary infection in our hospital were selected and divided into two groups according to their infection status. Group a was a total of 75 cases of children with mycoplasma infection,while group b was a total of 25 cases of children with bacterial infection. Twenty healthy children who came to our hospital for physical examination in the same period were selected as the control group. The c-reactive protein level and serum amyloid A level of the three groups were determined and analyzed by ROC curve. Results: The CRP level and SAA level of children in the control group were significantly lower than those in group a and b,and the CRP level and SAA level of children in group a were significantly lower than those in group b (all P < 0.05). SAA/CRP ratios were not significantly different among the three groups (all P > 0.05). SAA test has a high diagnostic accuracy for children with bacterial infection and mycoplasma infection,while CRP test only has a high diagnostic accuracy for children with bacterial infection and has little significance for the differential diagnosis of children with mycoplasma infection. Conclusion: The detection of CRP and SAA has high accuracy in the diagnosis of bacterial infection in children,and the detection of SAA in the diagnosis and differential diagnosis of mycoplasma pneumoniae infection in children is also of high application value. It is worth popularizing and applying in clinic.