小儿柴桂退热颗粒辅助治疗疱疹性咽峡炎患儿疗效与安全性及对血清lgA lgM的影响

The Efficacy and Safety of Xiaoer Chaigui Qure Granule in the Treatment of Herpetic Angina and its Effect on Serum LGA and LGM

目的:分析小儿柴桂退热颗粒辅助治疗疱疹性咽峡炎患儿疗效及血清lgA、lgM的影响。方法:选择2016年5月至2017年11月我院儿科收治的50例脾胃积热型疱疹性咽峡炎患儿,分别采用常规西药(对照组,n=25)和小儿柴桂退热颗粒联合西药(治疗组,n=25)进行治疗,比较两组患者中医证候量化病情分级表、观察记录临床症状缓解情况、测定免疫球蛋白A(lgA)及免疫球蛋白M(lgM)水平、临床疗效和不良反应。结果:两组患者治疗前病情等级比较无显著差异(Z=-1.084,P>0.05),治疗后治疗组中医证候总积分远远低于对照组(P<0.05);治疗组临床症状改善情况显著优于对照组(P<0.05);治疗前治疗组IgA、IgM水平与对照组无明显差异(P>0.05),治疗后两组IgA、IgM水平均高于治疗前(P<0.05),治疗组IgA、IgM水平显著高于对照组(P<0.05);治疗组总有效率(96.00%)远远大于对照组(68.00%)(χ^2=6.640,P<0.05),治疗组不良反应率(4.00%)远远低于对照组(28.00%)(χ^2=5.357,P<0.05)。结论:小儿柴桂退热颗粒辅助治疗疱疹性咽峡炎能有效缓解各项症状,显著提高lgA、lgM水平,安全性高,可在临床广泛推广。

Objective: To investigate effect of Xiaoer Chai GuiTuire granule on symptoms and serum lgA and lgM in children with herpangina. Methods: 50 cases of herpangina with accumulated heat in spleen and stomach type treated in our hospital from May 2016 to November 2017 were selected and divided into two groups according to the different treatment methods,each with 25 cases. The control group received the routine western medicine,while the treatment group received the Xiaoer Chai GuiTuire granule combined with western medicine. Then the TCM syndrome scores,clinical symptoms,immunoglobulin A (lgA) and immunoglobulin M (lgM) levels,clinical efficacy and adverse reactions were determined. Results: TCM syndrome scores had no difference before treatment (Z=-1.084,P>0.05),which were lower in the treatment group than in the control group after treatment (P<0.05). The improvement of clinical symptoms in the treatment group was significantly better than that in the control group (P<0.05). The levels of IgA and IgM had no difference before treatment (P>0.05),which were increased after treatment,and were higher in the treatment group than in the control group (P<0.05). The clinical efficacy of the treatment group was higher than that of the control group (96.00% vs 68.00%;χ^ 2=6.640,P<0.05). The incidence rate of the adverse reaction in the treatment group was lower than that of the control group (4.00% vs 28.00%,χ^ 2=5.357,P<0.05). Conclusion: The application of Xiaoer Chai GuiTuire granule is an effective and safe way to alleviate the various TCM symptoms,improve the lgA and lgM levels for children with herpangina,which is worthy of promotion.