琥珀酸索利那新治疗儿童膀胱过度活动症的研究概况

Research progress of solifenacin succinate in treatment of overactive bladder syndrome in children

膀胱过度活动症(overactive bladder,OAB)是一种以尿频、尿急症状为特征的症候群,严重影响儿童的生活,琥珀酸索利那新为新一代毒蕈碱乙酰胆碱(M受体)拮抗剂,对于膀胱逼尿肌具有高选择性,可明显缓解儿童OAB症状,小剂量琥珀酸索利那新用于治疗儿童OAB是安全、有效的。该文就琥珀酸索利那新治疗儿童OAB的研究概况作一综述。

Overactive bladder syndrome(OAB)is a group of syndromes characterized by frequent urination and urinary urgency,seriously effecting the quality of life in children with OAB.Solifenacin succinate is a new generation of muscarinic acetylcholine receptor(M receptor)antagonist with high selectivity for detrusor,and obviously relieves the symptoms of OAB in children.Small doses of solifenacin treatments for children with OAB are safe and effective.In this paper,we review the research progress of solifenacin succinate in treatment of OAB in children.