维生素K1血清浓度与婴幼儿凝血功能关系的临床研究进展

Clinical research progress on changes in serum concentrations of vitamin K1 and blood coagulation function in infants and young children

维生素K1(vitamin K1,VitK1)是婴幼儿凝血因子合成不可缺少的物质,由于在血清中的浓度变化较大,其不足与缺乏均可引起婴幼儿在血管损伤后出血不止,及时适量补充VitK1可使出血停止,但当剂量过大则会影响机体凝血功能。婴幼儿出生后凝血功能尚未发育完善,这与其血液循环生理相符合,在生长发育过程中会日臻完善;VitK1为机体合成凝血物质所必需,与婴幼儿凝血功能的完善关系密切。该文就VitK1血清浓度与婴幼儿凝血功能关系的临床研究进展作一综述。

Vitamin K1(VitK1)is indispensable as a cofactor for the synthesis of blood coagulation factors in infants and young children.Because of large changes of VitK 1 in serum concentration,the shortage and deficiency of VitK 1 can cause bleeding after blood vessel injury in infants and young children.Supplementing VitK 1 timely and adequately can stop the bleeding,while an excessive dosage can affect the blood coagulation function of the body.The blood coagulation function of infants and young children does not fully develop,which corresponds to the physiology of their blood circulation,and which will be perfected during growth and development.VitK1 is necessary for the synthesis of clotting substances,which is closely related to the improvement of blood coagulation function in infants and young children.In this paper,the relationship between serum concentration of VitK 1 and the blood coagulation function in infants and young children is reviewed.