抗生素相关性腹泻研究进展

Research Progress of Antibiotic-associated Diarrhea

抗生素相关性腹泻指与使用抗生素有关的无法用其他原因解释的腹泻。由于目前抗生素使用普遍,该病的发病率逐渐升高,如果不及时治疗,部分患者有引起毒性巨结肠甚至休克的风险,严重者可导致死亡。该文从临床表现、发病机制、疾病诊断、危险因素、治疗及预防措施等环节,阐述了抗生素相关性腹泻的研究进展,旨在为该病的防治及新药开发提供参考。

Antibiotic-associated diarrhea is defined as a diarrhea associated with the use of antibiotics which can not explain by other reason.Due to the widespread use of antibiotics currently, the incidence of disease is gradually increasing.If not treated promptly, some patients may be at risk of causing toxic megacolon and even shock,which can lead to death.In this paper,the research progress of antibiotic-associated diarrhea is expounded from the aspects of clinical manifestation,pathogenesis, disease diagnosis,risk factors,treatment and preventive measures,aiming at providing reference for the prevention and treatment of the disease and the development of new drugs.