抗菌药物用药频度与同期及非同期肠球菌耐药率相关性

Correlation Analysis on DDDs of Antibacterial Agents and Drug Resistance Rate of Enterococcus at the Same and Different Periods

目的了解肠球菌耐药率变化与抗菌药物使用的相关性,为控制肠球菌属细菌医院感染提供参考。方法采用回顾性调查分析方法,对某三甲医院2014-2017年肠球菌耐药情况及全院13类(43种)抗菌药物用药频度(DDDs)进行统计,将肠球菌耐药率分别与同期和非同期抗菌药物DDDs进行相关性分析。结果 2017上半年抗菌药物总DDDs较2016下半年下降63%;屎肠球菌对替考拉宁耐药率在2016上半年最高(2.2%),与同期唑烷酮类(利奈唑胺)和一年前氨基苷类DDDs正相关;粪肠球菌对青霉素G耐药率低于6.1%,与半年前唑烷酮类(利奈唑胺)DDDs正相关,粪肠球菌对利奈唑胺耐药率低于1.1%,与半年前头孢菌素DDDs正相关(P<0.05)。结论规范合理使用抗菌药物,控制抗菌药物DDDs,有助于延缓肠球菌属细菌耐药性发展。

Objective To understand the correlation between the resistance rate of Enterococcus and the use of antibacterial agents,and to provide reference for the control of hospital infection of Enterococcus. Methods The resistance rate of Enterococcus and the defined daily dose(DDDs) of 43 kinds of antibacterial agents in a first-class hospital at grade 3 from 2014 to 2017 were collected and analyzed retrospectively.Correlations between the drug resistance rate of enterococcus and DDDs of antibacterial agents at the same and different periods were carried out by using spearman correlation analysis. Results The total DDDs of antibacterial agents in the first half of 2017 decreased by 63% compared with the second half of 2016.The resistance rate of enterococcus faecium to teicoplanin was the highest(2.2%) in the first half of 2016,which was positively correlated with the DDDs of oxazolidinone(linezolid) of the same period and DDDs of aminoglycosides a year ago.The resistance rate of Enterococcus faecalis to penicillin G was lower than 6.1%,which was positively correlated with DDDs of oxazolidinone(linezolid) the last semi-annual.The resistance rate of Enterococcus faecalis to linezolid was less than 1.1%,which was positively correlated with the the last semi-annual DDDs of cephalosporin(P<0.05). Conclusion Standard and rational use of antibacterial agents and controlling their DDDs are helpful to reduce the drug resistance rate of Enterococcus.