新型标志物sST2对心力衰竭预后判断的价值

To study value of novel marker sST2 in prognosis of patients with heart failure

〔目的〕通过测定血清sST2浓度,探讨其对心力衰竭患者预后的判断价值。〔方法〕收集郑州大学第二附属医院心血管内科心力衰竭患者326例,并选择健康体检人员300例作为对照组,采用ELISA法分别测定其血清sST2浓度,根据患者出院后1年内再住院率分为心衰再入院组与心衰未入院组,记录入组时患者血清sST2。〔结果〕心衰组患者血清sST2水平(74.86±14.11)ng/mL,明显高于对照组(47.57±11.42)ng/mL,P<0.05;心衰再入院组sST2水平中位数为79.47 ng/mL,心衰未入院组sST2水平中位数为65.35 ng/mL,心衰再入院组sST2水平较心衰未入院组高(P<0.05)。〔结论〕血清sST2作为新型生物标志物来判断心衰患者的预后有一定临床价值。

〔Objective〕To determine the prognostic value of sST2 in patients with heart failure by measuring the concentration of sST2.〔Methods〕A total of 326 patients with heart failure were collected in department of cardiovascular in the Second Affiliated Hospital of Zhengzhou University, and selected 300 health checkups as a control group, the serum sST2 concentrations were determined by ELISA method in both groups, patients with heart failure were divided into re-hospitalized group and non- hospitalized group according to whether the patient was hospitalized within 1 year after discharge, the patient serum sST2 was recorded at the time of enrollment.〔Results〕Serum sST2 levels were (74. 86 ±14. 11) ng/mL in heart failure group and (47. 57 ±11. 42) ng/mL in control group, and increased in the heart failure group compared with the control group ( P < 0. 05), the median of sST2 level was 79. 47 ng/mL in heart failure re-admission group, and median of sST2 level was 65. 35 ng/mL in heart failure group, the sST2 level in heart failure re-admission group was higher than that in heart failure group.〔Conclusion〕Serum sST2 as a novel biomarker to determine the prognosis of patients with heart failure has certain clinical value.