间苯三酚在绝经后妇女宫腔镜检查前促宫颈成熟的效果分析

Comparison of phloroglucinol and misoprostol for cervical ripening before hysteroscopy in postmenopausal women

〔目的〕检测间苯三酚用于绝经后妇女宫腔镜检查前促宫颈成熟的效果。〔方法〕随机双盲对照研究,将90例绝经后行宫腔镜检查的患者分为3组,间苯三酚组30例,宫腔镜检查前15 min静脉推注间苯三酚60 mg;米索前列醇组30例,宫腔镜检查前4 h舌下含化米索前列醇片400μg;对照组宫腔镜检查前不给予任何药物。以检查术中需要进行宫颈扩张的患者数作为主要指标,检查前宫颈宽度比较作为次要指标,其他指标包括宫颈扩张时间比较、宫颈扩张难易度、用药后副作用比较。〔结果〕对照组23名患者需要宫颈扩张,米索前列醇组17名患者需要宫颈扩张,间苯三酚组9名患者需要宫颈扩张。对照组、米索前列醇和间苯三酚组的患者检查前平均宫颈宽度为(4.23±0.43)mm、(5.43±0.52)mm、(5.83±0.64)mm。〔结论〕间苯三酚用于绝经后妇女宫腔镜检查前促宫颈成熟比米索前列醇效果好。

〔Objective〕To compare the effectiveness of phloroglucinol and misoprostol for cervical ripening before diagnostic hysteroscopy in postmenopausal women.〔Methods 〕A randomized, double-blind, controlled study of 90 patients with postmenopausal hysteroscopy was divided into 3 groups, 30 patients in the phloroglucin group, and 60 mg phloroglucinol was given intravenously 15 minutes before hysteroscopy. Thirty patients in the misoprostol group received 400 μg of sublingual misoprostol tablets 4 hours before hysteroscopy. No drug was given before the hysteroscopy in the control group. The number of patients requiring cervical dilatation during operation was used as the main index. The comparison of anterior cervical width was used as a secondary index. Other indicators included comparison of cervical dilatation time, difficulty in cervical dilatation, and side effects after medication.〔Results〕In the control group, 23 patients required cervical dilatation, compared with 17 in the misoprostol group and 9 in the phloroglucinol group. In the control group, patients with misoprostol and phloroglucinol had an average cervical width of (4. 23 ± 0. 43) mm,(5. 43 ± 0. 52) mm, and (5. 83 ± 0. 64) mm before examination.〔Conclusion〕 phloroglucinol before diagnostic hysteroscopy is more effective than misoprostol for inducing cervical priming.