胃癌患者血清白细胞介素-6、C-反应蛋白和血管内皮生长因子的表达及其临床意义

Expression levels and clinical significance of serum interleukin-6, C-reactive protein, and vascular endothelial growth factor in patients with gastric cancer

目的探究血清白细胞介素-6(IL-6)及相关因子C-反应蛋白(CRP)、血管内皮生长因子(VEGF)在胃癌患者中的表达水平及其临床意义。方法选取2015年9月至2017年9月空军军医大学附属唐都医院消化科收治的68例胃癌患者为胃癌组,同期收治的72例胃良性病变患者作为胃良性病变组,同期体检健康者70例作为健康对照组;比较三组受检者的血清IL-6、VEGF、CRP水平,同时比较胃癌组中不同病理分期组、有无淋巴结转移患者的血清IL-6、VEGF、CRP水平;并分析VEGF、CRP表达与血清IL-6的相关性。结果胃癌组和胃良性病变组患者的血清IL-6、VEGF、CRP水平均明显高于健康对照组,而胃癌组患者的血清IL-6、VEGF、CRP水平又明显高于胃良性病变组,差异均有统计学意义(P<0.05);胃癌组中Ⅲ~Ⅳ期患者的血清IL-6、VEGF、CRP水平分别(54.68±7.16)pg/mL、(95.41±12.37)%、(14.88±2.26)mg/L,明显高于Ⅰ~Ⅱ期的(29.67±4.02)pg/mL、(63.58±8.26)%、(9.72±1.68)mg/L,差异均有统计学意义(P<0.05);胃癌组中有淋巴结转移患者的血清IL-6、VEGF、CRP水平分别(56.81±7.22)pg/mL、(92.03±12.24)%、(15.02±2.62)mg/L,明显高于无淋巴结转移患者的(26.34±3.89)pg/mL、(66.81±8.38)%、(9.51±1.61)mg/L,差异均有统计学意义(P<0.05);Pearson相关分析结果显示,VEGF、CRP表达与血清IL-6水平均呈正相关(r=0.993、0.973,P<0.05)。结论血清IL-6、VEGF、CRP与胃癌的发生发展关系密切,可作为反映胃癌进展的标志物。

Objective To investigate the expression levels and their clinical significance of serum interleukin- 6 (IL-6) and related factors such as C-reactive protein (CRP) and vascular endothelial growth factor (VEGF) in gastric cancer patient. Methods From September 2015 to September 2017, 68 patients with gastric cancer admitted to the Department of Gastroenterology at Tangdu Hospital of Air Force Medical University were enrolled into a gastric cancer group;72 patients with benign gastric lesions were selected as a benign gastric lesions group, and 70 healthy people who underwent physical examination at the same time were selected as a healthy group. The serum levels of IL-6, VEGF and CRP in the three groups were compared, as well as each serum levels in patients with different pathological stages and in patients with or without lymph node metastasis;then the correlation was analyzed between the expression of VEGF and CRP and serum IL-6. Results The serum levels of IL-6, VEGF and CRP were significantly higher in patients with gastric cancer and benign gastric lesions than in healthy individuals;and the serum levels of IL-6, VEGF and CRP were significantly higher in patients with gastric cancer than in patients with benign gastric lesion;all differences were statistically significant (P<0.05). In the gastric cancer group, the serum levels of IL-6, VEGF and CRP were (54.68±7.16) pg/mL,(95.41±12.37)%, and (14.88±2.26) mg/L in patients with stage Ⅲ to Ⅳ respectively, which were significantly higher than corresponding (29.67±4.02) pg/mL,(63.58±8.26)%, and (9.72±1.68) mg/L in patients with stage Ⅰ to Ⅱ(P<0.05). The serum levels of IL-6, VEGF, and CRP levels in the gastric cancer group were (56.81±7.22) pg/mL,(92.03±12.24)%, and (15.02±2.62) mg/L in patients with lymph node metastasis, respectively, which were significantly higher than corresponding (26.34±3.89) pg/mL,(66.81±8.38)%, and (9.51±1.61) mg/L in patients without lymph node metastasis (P< 0.05). Pearson correlation analysis showed that there was a positive correlation between the expression of VEGF and CRP and serum level of IL-6 (r=0.993 and 0.973, respectively;both P<0.05). Conclusion The serum levels of IL-6, VEGF and CRP are closely related to the occurrence and development of gastric cancer, which can be used as a marker to reflect the gastric cancer progression.