3种药物在足月妊娠引产中的临床效果对比

Comparison of Clinical Effects of Three Drugs in Induced Abortion of Full-Term Pregnancy

目的探讨地诺前列酮、米索前列醇与缩宫素这3种药物在足月妊娠引产中起到的效果及其安全性。方法选取2016年6-2019年6月于我院足月妊娠产妇中的120例作为研究对象。将应用地诺前列酮、米索前列醇及缩宫素引产的产妇分成3组,每组各取40例。对其用药前、后宫颈Bishop评分变化情况、产程时长变化情况及产妇分娩方式及结局情况进行对比。结果用药后的宫颈Bishop评分情况行两两对比,地诺前列酮组得分高于米索前列醇组高于缩宫素组(P<0.05)。第一产程时长情况行两两对比,地诺前列酮组用时短于米索前列醇组短于缩宫素组(P<0.05)。阴道分娩率对比,缩宫素组大于地诺前列酮组大于米索前列醇组(P<0.05)。结论地诺前列酮及米索前列醇均有良好的促进宫颈成熟效果,引产速度较快。但由于个体差异,应用缩宫素后阴道分娩成功的可能性更大,故联合用药效果更佳。

Objective To explore the efficacy and safety of three drugs, dinoprostone, misoprostol and oxytocin, in induced labor of full-term pregnancy. Methods 120 full-term pregnant women in our hospital from June 2016 to June 2019 were selected as the study subjects.The parturients induced by dinoprostone, misoprostol and oxytocin were divided into three groups, 40 cases in each group.The changes of cervical Bishop score, duration of labor, delivery mode and outcome before and after treatment were compared. Results The Bishop scores of cervix after administration were compared in two ways. The scores of dinoprostone group were higher than those of misoprostol group and oxytocin group (P < 0.05). The duration of the first stage of labor was compared in two ways. The duration of dinoprostone group was shorter than misoprostol group and shorter than oxytocin group (P < 0.05). The rate of vaginal delivery in oxytocin group was higher than that in dinoprostone group and misoprostol group (P < 0.05). Conclusion Both dinoprostone and misoprostol have good effects on promoting cervical ripening, and the induction of labor is faster. However, due to individual difTerences, the use of oxytocin after vaginal delivery is more likely to succeed, so the combined use of drugs is better.