一步法合成18F-PSMA-1007及其对前列腺癌的PET/CT显像

Synthesis of 18F-PSMA-1007 by one-step method and PET/CT imaging in prostate cancer

目的合成18F-前列腺特异膜抗原(PSMA)-1007并进行前列腺癌显像。方法基于一步标记法,利用CFN-MPS-200型自动合成模块合成18F-PSMA-1007,并对产品进行质量分析,同时对1例前列腺癌患者(66岁)进行18F-PSMA-1007 PET/CT显像。结果自动化合成18F-PSMA-1007的时间约为50 min,合成产率为(25.0±5.0)%(衰减校正后,n=3),放化纯大于99.0%,在6 h后放化纯仍大于98.0%。产品为无色透明溶液,pH值为7.0~7.5,比活度为(410.0±11.0) MBq/ml,其核素纯度大于99.0%。患者PET/CT显像示18F-PSMA-1007高度浓聚于前列腺癌灶,最大标准摄取值(SUVmax)为40.9。结论基于CFN-MPS-200多功能合成模块合成18F-PSMA-1007的方法稳定,合成产率高,药物可浓聚于前列腺癌灶。

Objective To synthesize and analyze 18F-prostate specific membrane antigen (PSMA)-1007, followed by its imaging in prostate cancer. Methods Based on one-step method, 18F-PSMA-1007 was produced by the CFN-MPS-200 automatic synthesis module and its quality analysis was conducted. 18F-PSMA-1007 PET/CT imaging was performed in a prostate cancer patient (66 years old). Results The synthesis time of 18F-PSMA-1007 was about 50 min, and the radiochemical yield was (25.0±5.0)%(attenuation correction, n=3). The radiochemical purity was above 99.0% and was above 98.0% after 6 h. The product was colorless transparent solution with pH value of 7.0-7.5, and the specific activity was (410.0±11.0) MBq/ml and the radioactive nuclear purity was above 99.0%. PET/CT imaging in the patient showed that 18F-PSMA-1007 was highly concentrated in prostate cancer with maximum standardized uptake value (SUVmax) of 40.9. Conclusion Based on CFN-MPS-200 multifunction synthesis module, 18F-PSMA-1007 can be stably synthesized with high radiochemical yield and can be concentrated in prostate cancer.