CSF外泌体在CNS疾病诊断与应用价值的研究进展

Research progress on diagnosis and application value of CSF exosome in CNS disease

外泌体是由细胞内多囊泡体与细胞膜融合释放到胞外的囊泡。外泌体由多种细胞分泌,存在于多种体液中。外泌体中含有蛋白质、脂质和核酸,可参与细胞间的信息交流。CNS细胞分泌的外泌体参与了CNS疾病发生发展过程。研究表明,外泌体不仅可以作为CNS疾病的早期诊断标志物,对CNS疾病也具有治疗潜能。本文着重阐述了CSF中外泌体在CNS疾病发生发展及诊治中的研究进展。

Exosomes are vesicles released into extracellular cells by fusion of intracellular polyvesicles and cell membranes. Exosomes are secreted by a variety of cells and exist in a variety of body fluids. Exosomes contain proteins, lipids and nucleic acids, which can participate in the information exchange between cells. Exosomes secreted by CNS cells are involved in the occurrence and development of CNS diseases. Recent studies have shown that exosomes can not only serve as early diagnostic markers for CNS diseases, but also have therapeutic potential for CNS diseases. In this paper, the development, diagnosis and treatment of CSF exosomes in CNS diseases were reviewed.