男性2型糖尿病患者并发良性甲状腺结节的激素水平特征分析

Hormone Level Characteristics of Male Type 2 Diabetes Mellitus Complicated with Benign Thyroid Nodules

目的 分析男性2型糖尿病(T2DM )患者并发良性甲状腺结节(NG)的激素水平特征。方法 选择辽宁省人民医院2015年4月-2019年4月收治的男性T2DM患者367例,分为非结节组164例和结节组203例(包括小结节亚组92例、中结节亚组64例和大结节亚组47例),对各组间激素水平进行比较。结果 非结节组和结节组促甲状腺激素(TSH)和黄体生成素(LH)差异有统计学意义(P<0.05),而其余指标差异无统计学意义(P>0.05)。小结节亚组、中结节亚组和大结节亚组TSH分别为(1.9±0.2)μIU/L、(2.8±0.4)μIU/L和(3.6±0.5)μIU/L,差异有统计学意义(P<0.05);LH分别为(7.3±1.9)mIU/L、(8.0±2.2)mIU/L和(8.9±2.6)mIU/L,差异有统计学意义(P<0.05)。对结节直径分别与T SH和LH进行相关性分析显示,均呈正相关关系(P<0.05)。结论 T SH和LH失衡与男性T2D M患者良性NG发病关系密切,临床对于患T2DM且TSH和LH升高的患者,应定期检查甲状腺超声。

Objective To analyze the hormone levels in male type 2 diabetes mellitus (T2DM) patients with benign thyroid nodules (NG). Methods Atotal of 367 male patients with T2DM admitted to our hospital from April 2015 to April 2019 were divided into non-nodular group (164 cases) and nodular group (203 cases, including 92 cases of small nodule subgroup, 64 cases of middle nodule subgroup and 47 cases of large nodule subgroup). The hormone levels were compared in different groups. Results There were significant differences in TSH and LH between non-nodular group and nodular group (P<0.05), while there was no significant difference in other indexes (P>0.05). The TSH in the small nodule subgroup, the middle nodule subgroup and the large nodule subgroup were (1.9±0.2)μIU/L,(2.8±0.4)μIU/Land (3.6±0.5)μIU/L, respectively,with significant difference (P<0.05);theLH were (7.3±1.9) mIU/L,(8.0±2.2) mIU/L and (8.9±2.6) mIU/L, respectively, with significant difference (P<0.05). The correlation analysis of nodule diameter with TSH and LH showed a significantly positive correlation (P<0.05). Conclusion The imbalance of TSH and LH is closely related to benign NG in male patients with T2DM. Thyroid ultrasound should be regularly adopted in patients with T2DM with elevated TSH and LH.