脂肪分布的性别差异对高血压患者肥胖指标与动脉僵硬度关系的影响

The effect of gender differences in fat distribution on the relationship between obesity index and arterial stiffness in patients with hypertension

目的分析反映不同肥胖类型的指标在高血压患者中与动脉僵硬度的相关性的性别差异。方法选取2014年至2018年徐州市中心医院就诊的304名高血压患者,测量体重、身高、腰围(WC)、臀围(HC)。体质指数(BMI)、腰臀比(WHR)、腰高比(WHtR)均依据体重、身高、WC、HC计算。动脉僵硬度用颈-股脉搏波传播速率(carotid-femoral pulse wave,cfPWV)表示。肥胖的不同类型指标与动脉僵硬度之间的关联用线性回归模型分析。结果总人群中 cfPWV与WC(0=O.O28,P<O.O5)、WHtR(0=6.O76,P<O.O5)独立相关。男性 WHtR 与cfPWV呈正相关(β= 6.692,P<0.05),女性中只有HC与cfPWV相关(β=O.O69,P<O.O5)。结论在总人群中WC、WHtR与cfPWV均呈正相关;性别的差异影响高血压患者肥胖指标与动脉僵硬度的关联,HC在女性高血压患者中与cfPWV正相关,在男性高血压患者中WHtR与动脉僵硬度有更好的关联性。

Objective To analyze the gender differences in the correlation between different obesity types and arterial stiffness in patients with hypertension. Methods A total of 304 patients with hypertension were selected from Xuzhou Central Hospital from 2014 to 2018. Their weight, height, waist circumference ( WC) and hip circumference (HC) were measured. Body mass index ( BMI), waist - to - hip ratio ( WHR), waist - to - height ratio ( WHtR) are calculated according to body weight, height, WC and HC. Arterial stiffness was expressed by carotid - femoral pulse wave ( cfPWV). Linear regression model was used to analyze the relationship between different types of obesity and arterial stiffness. Results Regardless of gender, cfPWV was independendy correlated with WC (β= 0. 028, P < 0. 05 ) and WHtR (β= 6.076, P <0.05). In males, WHtR was positively correlated with cfPWV (β= 6. 692, P < 0. 05 ), while in females, only HC was correlated with cfPWV (β= 0.069, P <0.05). Conclusions WC, WHtR and c￡PWV are positively correlated in the total population. Gender differences affect the correlation between obesity index and arterial stiffness in patients with hypertension. HC is positively correlated with cfPWV in female with hypertension. WHtR is better correlated with arterial stiffness in male with hypertension.