序贯疗法与标准三联疗法治疗幽门螺杆菌阳性胃溃疡临床对比观察

Clinical observation of sequential therapy and standard triple therapy in treating helicobacter pylori positive gastric ulcer

目的对序贯疗法与标准三联疗法治疗幽门螺杆菌阳性胃溃疡临床治疗效果进行对比观察。方法选取2017年3月至2019年3月本院确诊的幽门螺杆菌阳性胃溃疡患者74例,根据患者入院时间将其分为实验组和对照组,各37例。两组患者分别给予序贯疗法和标准三联疗法进行治疗,对两组患者的临床治疗效果进行对比。结果实验组和对照组的治疗总有效例数为34例和26例,治疗总有效率分别为91.89%和70.27%,溃疡愈合总例数分别为23例和11例,溃疡总愈合率分别为62.16%和29.72%,不良反应发生例数分别为4例和10例,不良反应总发生率为10.81%和27.02%,组间对比差异具有统计学意义(P<0.05)。结论对幽门螺杆菌阳性胃溃疡患者进行临床治疗,相对传统的标准三联治疗,序贯疗法的治疗效果更好,有利于提高患者对治疗的耐受程度,增加患者的溃疡愈合速度,减少患者的不良反应,同时有利于提高患者的生活质量,因此序贯疗法对于幽门螺杆菌阳性胃溃疡患者具有较高的临床应用价值。

Objective To compare the clinical effects of sequential therapy and standard triple therapy in the treatment of Helicobacter pyloripositive gastric ulcer.Methods 74 patients with Helicobacter pylori-positive gastric ulcer diagnosed in our hospital from March 2017 to March 2019 were divided into experimental group and control group according to the patient' s admission time,with 37 patients in each group.The two groups of patients were treated with sequential therapy and standard triple therapy,and the clinical effects of the two groups were compared.Results The total effective number of patients in the experimental group and the control group was 34 cases and 26 cases,the total effective rate was 91.89% and 70.27%,respectively.The total number of ulcer healing was 23 cases and 11 cases respectively.The total ulcer healing rate was 62.16% and 29.72%, the number of adverse reactions occurred in 4 cases and 10 cases respectively.The total incidence of adverse reactions was 10.81% and 27.02%,the difference between groups was statistically significant (P<0.05).Conclusion The clinical treatment of patients with Helicobacter pylori-positive gastric ulcer is better than the traditional standard triple therapy.The therapeutic effect of sequential therapy is better,which is beneficial to improve the patient' s tolerance to treatment,increase the ulcer healing rate and reduce the ulcer healing rate.The patient' s adverse reactions are also conducive to improve the quality of life of patients,so sequential therapy has a high clinical value for patients with Helicobacter pylori positive gastric ulcer.