奥卡西平治疗对癫痫患者Hcy与CRP及认知功能的影响

Effect of oxcarbazepine on Hcy, CRP and cognitive function in epileptic patients

目的分析对癫痫患者给予奥卡西平治疗的效果及对患者血清同型半胱氨酸(Hcy)、C反应蛋白(CRP)指标及认知功能的影响效果。方法将本院神经内科2016年3月至2018年3月收治的90例癫痫患者进行观察,采用随机数字表法将患者分成实验组和对照组,各45例。对照组给予常规抗癫痫治疗,实验组给予奥卡西平治疗。治疗12周,观察比较两组治疗前后Hcy、CRP指标及认知功能变化。结果实验组、对照组Hcy、CRP指标均高于治疗前(P<0.05);实验组治疗前后Hcy、CRP指标与对照组比较差异均无统计学意义;实验组PIQ、VIQ、FIQ较治疗前明显改善且改善情况优于对照组(P<0.05)。结论癫痫患者给予奥卡西平对Hcy、CRP指标存在影响,但能有效缓解患者临床症状,提高患者认知功能,改善患者生活质量及预后,值得推广。

Objective To analyze the effect of oxcarbazepine on patients with epilepsy and its effect on serum homocysteine (Hcy),C-reactive protein (CRP) and cognitive function.Methods 90 epileptic patients admitted to the department of Neurology of our hospital from March 2016 to March 2018 were observed.The patients were divided into experimental group and control group,with 45 cases in each group.The control group was given conventional antiepileptic treatment,while the experimental group was given oxcarbazepine.After treatment for 12 weeks,the changes of Hcy,CRP and cognitive function were compared between the two groups before and after treatment.Results The indexes of Hcy and CRP in the experimental group and the control group were all higher than that before the treatment (P<0.05),and there was no significant difference in the Hcy and CRP indexes between the experimental group and the control group before and after the treatment,while the PIQ,VIQ and FIQ in the experimental group were obviously better than those before the treatment and the improvement was better than the control group (P<0.05).Conclusion The effect of oxcarbazepine on the index of Hcy and CRP is effective,but it can effectively relieve the clinical symptoms,improve the cognitive function of the patients,improve the quality of life and prognosis of the patients.It is worth promoting.