声动力治疗在动脉粥样硬化中的应用进展

Progress in the application of sonodynamic therapy in atherosclerosis

动脉粥样硬化是一种慢性血管性病变,发病率和死亡率均很高,虽然目前的治疗手段取得了一定的治疗效果,但存在治疗周期长、不良反应大、有侵入性的特点。声动力治疗(SDT)因其具有非侵入性,局部治疗对正常的组织影响较小、组织穿透能力强且能量无明显衰减等优点,成为目前研究的热点。SDT可引起细胞凋亡和自噬,具有改善脂质沉积、减少炎性细胞浸润、促进血管平滑肌细胞增殖、防止基质降解等作用,对动脉粥样硬化是一种很有潜力的治疗手段。本文就SDT对动脉粥样硬化的作用及其机制进行综述。

Atherosclerosis is a chronic vascular disease with high morbidity and mortality. Although the current treatment has achieved certain therapeutic effects, it has the characteristics of long treatment cycle, large adverse reactions and invasiveness. Sonodynamic therapy (SDT) has become a hot topic in current research because of its non-invasive nature, less impact on normal tissues, strong tissue penetration and no significant attenuation of energy. SDT can cause cell apoptosis and autophagy, improve lipid deposition, reduce inflammatory cell infiltration, promote vascular smooth muscle cell repopulation and prevent matrix degradation, and it is a potential treatment for atherosclerosis. The effects of SDT on atherosclerosis and its mechanisms are summarized below.