水相中微波辅助镍催化合成四氮唑异喹啉衍生物的研究

Microwave-assisted nickel-catalyzed synthesis of tetrazoloisoquinolines

开展了取代5-(2-卤代苯基)-1 H四唑与炔烃为原料在镍(Ⅱ)盐催化串联反应生成四氮唑[5,1-α]异喹啉衍生物的微波辅助合成研究。结果表明:相同反应时间,在镍催化微波辅助条件下,生成四氮唑[5,1-α]异喹啉衍生物的效率较常规加热条件下增强。一系列四氮唑[5,1-α]异喹啉衍生物被高效地合成出来,最高产率达到88%。产物结构经1H NMR、13 C NMR及MS得到确证。该方法具有产率高、操作简单、环境友好等优点。

Microwave-assisted organic nickel-catalyzed synthesis of tetrazolo[5,1-α]isoquinolines through the reaction of 5-(2-halophenyl)-1 H -tetrazoles and alkynes was investigated.The results showed the yield was improved significantly when the reaction was carried out under Nickel-catalyzed microwave irradiation.A variety of tetrazolo[5,1-α]isoquinolines could be synthesizedin moderate to good yields up to 88%.The structures of all compounds were confirmed by 1H NMR, 13 C NMR and MS analysis.This method had the advantages of good yields,easy work-up and environmentally friendly procedure.