摘要
动脉粥样硬化是一种长期、缓慢进展的退行性炎性疾病;血凝集素样氧化型低密度脂蛋白受体-1(LOX-1)是氧化型低密度脂蛋白在内皮细胞上的主要受体,通过促进内皮细胞功能失调、单核细胞黏附、平滑肌细胞迁移和泡沫细胞形成等过程参与动脉粥样硬化的发生发展。LOX-1还可通过诱导巨噬细胞释放基质金属蛋白酶影响动脉斑块的稳定性。研究LOX-1在动脉粥样硬化形成中的机制可为心血管疾病提供新的诊疗思路。
Atherosclerosis is a long-term,slowly progressive degenerative inflammatory disease;lectin-like oxidized lowdensity lipoprotein receptor-1( LOX-1) is the major receptor on endothelial cells of oxidized low-density lipoprotein involved in the development of atherosclerosis,by promoting endothelial dysfunction,monocyte adhesion,smooth muscle cell migration and foam cell formation. LOX-1 also affects the stability of arterial plaques by inducing release of matrix metalloproteinases from macrophage. Studying the role of LOX-1 in the development of atherosclerosis can provide new ideas for the diagnosis and treatment of cardiovascular disease.
作者
秦雅红
张振刚
焦云根
QIN Yahong;ZHANG Zhengang;JIAO Yungen(Medical College of Yangzhou University,Yangzhou 225000,China;Department of Cardiology,Affiliated Hospital of Yangzhou University,Yangzhou 225000,China)
出处
《医学综述》
2019年第20期3969-3974,共6页
Medical Recapitulate
基金
扬州市“十三五”科教强卫专项经费资助(重点人才ZDRC201817)
