睡眠时间与骨质疏松症相关性的研究进展

Research Progress in Relationship between Sleep Time and Osteoporosis

骨质疏松症(OP)是一种常见的慢性疾病,其临床表现缺乏特异性,不易被发现,外伤致骨折后会产生多种并发症,不仅严重影响了患者的生活质量,还可增加病死率和医疗经济负担。睡眠是一种维持精力、保持和增进身体健康的重要生理活动。随着工作节奏加快,娱乐方式多样化,越来越多的人出现睡眠问题,包括睡眠不足、过多或晚睡。近年来,睡眠时长和入睡时间与OP的关系备受人们关注。睡眠不足或晚睡时,睡眠调控激素代谢紊乱,炎症因子水平升高,使骨吸收大于骨形成,从而促使OP发生。未来,可监测客观睡眠时间,并进一步探索睡眠不足、过多及晚睡与OP相关的机制。

Osteoporosis( OP) is a common chronic disease that lacks specific clinical manifestations and is difficult to detect. A variety of complications occur after trauma,which not only seriously affects the quality of life of the patients,but also increases the mortality rate and increases the medical economic burden. Sleep is an important physiological activity that maintains energy,maintains and improves health. As the pace of work accelerates and the entertainment is diversified,more and more people are having sleeping problems,including lack of sleep,excessive sleep,or late sleep. In recent years,the relationship between sleep duration and bedtime and OP has attracted much attention. When sleep is insufficient or bedtime is late,sleep regulating hormone metabolism gets disordered,and inflammatory factors increase,making bone resorption greater than bone formation,which promotes the occurrence of OP. In the future,objective sleep time can be monitored,to further explore the mechanisms associated with sleep deprivation,excessive sleep,and late sleep with OP.