摘要
糖尿病是以慢性血浆葡萄糖水平升高为特征的代谢性疾病。我国以2型糖尿病(T2DM)最常见,T2DM可导致患者出现多种严重并发症,影响其预后和生活质量。糖尿病骨病(DBD)是常见的T2DM慢性并发症之一,DBD患者的骨折风险、致残率和致死率均明显升高,严重者可致残。高糖环境、细胞因子和血管因素等是影响DBD发病的主要因素,骨小梁评分等多种骨折风险预测方法的应用对预防和治疗DBD骨折具有重要意义。
Diabetes mellitus is a metabolic disease characterized by chronic elevated plasma glucose levels. Type 2 diabetes mellitus( T2 DM) is the most common type in China. T2 DM can lead to many serious complications and affect the prognosis and quality of life of patients. Diabetic bone disease( DBD) is one of the common chronic complications of T2DM.The fracture risk,disability rate and fatality rate of DBD patients are significantly increased,and in severe cases patients can be disabled. High glucose environment,cytokines and vascular factors are the main factors affecting the onset of DBD. The application of various fracture risk prediction methods,such as bone trabecular score,is of great significance for the prevention and treatment of DBD fracture.
作者
焦璇
刘婷婷
黄勤
JIAO Xuan;LIU Tingting;HUANG Qin(Department of Endocrinology,the First Affiliated Hospital of Naval Medical University,Shanghai 200433,China)
出处
《医学综述》
2019年第20期4074-4079,共6页
Medical Recapitulate
基金
国家自然科学基金(81272665,81471038)
吴阶平医学基金会临床科研专项基金(PC20171002)
关键词
糖尿病
糖尿病骨病
骨折
Diabetes mellitus
Diabetic bone disease
Fracture
