肺炎链球菌感染的临床分布、耐药性变化趋势与抗菌药物的相关性分析

The Clinical distribution of Streptococcus pneumoniae infection and correlation analysis between the change in drug resistance and antibiotics

目的 肺炎链球菌是我院检出数较多的致病菌,通过临床分布、耐药性变化趋势与抗菌药物使用的相关性分析,旨在了解菌群特征,为临床治疗提供参考。方法 对各科所有标本进行分离培养和药敏试验,耐药数据与抗菌药物使用数据通过SPSS统计分析。结果 近3年共分离肺炎链球菌476株,主要引起婴幼儿呼吸道感染,对红霉素、克林霉素的耐药率较高,对头孢呋辛钠的耐药率总体呈现上升的趋势,其耐药性与抗菌药物的使用呈显著正相关性。结论 临床治疗肺炎链球菌引起的感染时应避免克林霉素、红霉素和头孢呋辛;抗菌药物间对耐药性影响是交错的,减少单一类抗菌药物的使用,效果不理想,只有综合的降低抗菌药物的使用,才能有效遏制细菌耐药;其耐药性逐年变化,需加强监测。

Objective Streptococcus pneumoniae is the most common pathogen detected in hospital. Through analysis clinical distribution, correlation between drug resistance and antibiotic, it aims to grasp the characteristics of the flora and provide reference for clinical treatment. Methods All specimens were isolated, cultured and tested for drug sensitivity. Drug resistance data and antimicrobial use data were analyzed by SPSS. Results 476 strains of Streptococcus pneumoniae were isolated in the past three years. It mainly causes respiratory tract infection in infants and young children. The resistance rate to erythromycin and clindamycin was high, and the resistance rate to cefuroxime sodium showed an overall upward trend. The drug resistance of Streptococcus pneumoniae was positively correlated with the use of antibiotics.Conclusion Clindamycin and erythromycin should be avoided in clinical treatment of infection caused by Streptococcus pneumoniae;Its drug resistance changes year by year, and monitoring needs to be strengthened;The effect of antibiotics on drug resistance is staggered. Reducing single-type antibiotic, the effect is not ideal. Only comprehensive reduction of the use of antibacterial drugs can achieve full containment of bacterial resistance.