胸部肿瘤术后患者认知功能障碍与血清S-100B蛋白浓度变化的相关性研究

Study on the Correlation Between Cognitive Impairment and Serum S-100B Protein Concentration in Patients with Thoracic Cancer after Operation

目的探讨胸部肿瘤术后患者认知功能障碍与血清S-100B蛋白浓度的相关性。方法回顾性分析2016年7月-2018年1月在我院接受胸部外科手术治疗的60例胸部肿瘤手术患者的临床资料,术后7d,所有入选者均需经中国韦氏成人智力量表(Wechsler Adult Intelligence Scale,WAIS)评估认知功能障碍情况,依据评估结果,将其分为对照组(未发生认知障碍患者,30例)与观察组(术后认知障碍患者,30例),分别于术前、术后1h、术后24h测定血清S-100B蛋白浓度,分析检测结果。结果术前,两组血清S100B蛋白浓度对比,差异无统计学意义(P>0.05);术后1h与24h,观察组血清S100B蛋白浓度均高于对照组,差异有统计学意义(P<0.05);不同认知功能障碍程度患者WAIS量表评分与血清S100B蛋白浓度对比,差异有统计学意义(P<0.05);经Pearson相关性分析显示,WAIS量表评分与血清S100B蛋白浓度呈负相关性(r<0,P<0.05)。结论胸部肿瘤术后患者认知功能障碍严重程度与其血清S100B蛋白高表达密切相关,临床应实时监测该指标水平,并及时给予对应干预措施。

Objective To investigate the correlation between cognitive dysfunction and serum S-100B protein concentration in patients with thoracic cancer after operation.Methods The clinical data of 60 patients with thoracic tumors who underwent thoracic surgery in our hospital from July 2016 to January 2018 were retrospectively analyzed.Seven days after surgery,all the patients were assessed by Wechsler Adult Intelligence Scale (WAIS).According to the results,they were divided into a control group (without cognitive impairment) and an observation group (with cognitive impairment) with 30 patients in each group.Serum S-100B protein levels were measured before operation,1 hour after operation and 24 hours after operation in each group.Results Before operation,there was no significant difference in serum S100B protein concentration between the two groups( P >0.05);1 hour and 24 hours after operation,the serum S100B protein concentration in the observation group was higher than that in the control group,with significant difference( P <0.05);WAIS scale score and serum S100B protein concentration in patients with different degrees of cognitive impairment were significantly different( P <0.05);The correlation analysis showed that the degree of cognitive impairment was negatively correlated with the concentration of serum S100B protein ( r<0,P <0.05).Conclusion The severity of cognitive impairment in patients with thoracic cancer after operation is closely related to the high expression of serum S100B protein.The level of this index should be monitored in real time and corresponding interventions should be given in time.