摘要
脑出血是一类具有高致残率和高致死率的卒中亚型,导致严重的社会经济负担,其发病和预后与环境、遗传等多种因素相关。载脂蛋白E(apolipoprotein E,AopE)是一种重要的脂质转运蛋白,在外周和中枢神经系统脂质代谢中均发挥重要作用。近年来,有关ApoE基因多态性与脑出血相关性的研究不断增加,本文就ApoE基因多态性与脑出血流行病学、发病特点、预后、治疗的研究成果和进展进行综述。
Intracerebral hemorrhage (ICH) is a common type of stroke with high disability and mortality, which causes serious social economic load. The morbidity and prognosis of ICH is associated with the multiple factors including environment and heredity. Apolipoprotein E (AopE) plays an important role in lipid metabolism in both peripheral circulation and central nervous system. In recent years, researches on the relationship between ApoE genetics polymorphisms and ICH have been deepened. In this review, we will briefly summarize the advances in the epidemiology, pathogenesis, prognosis and treatment of ICH associated with ApoE genetics polymorphisms.
作者
张高祺
杨琼
樊东升
ZHANG Gao-qi;YANG Qiong;FAN Dong-sheng(Department of Neurology,Peking University Third Hospital,Beijing 100191,China)
出处
《中国医学前沿杂志（电子版）》
2019年第10期1-6,I0001,共7页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
北京市科技计划项目（D141100000114005）
关键词
脑出血
载脂蛋白E
基因多态性
Intracerebral hemorrhage
Apolipoprotein E
Genetics polymorphism
