组织间插植近距离治疗和腔内近距离治疗对局部晚期宫颈癌患者生存期和生存质量的影响

Effect of interstitial brachytherapy and intracavitary brachytherapy on survival and quality of life in patients with locally advanced cervical cancer

目的探讨组织间插植近距离治疗和腔内近距离治疗对局部晚期宫颈癌患者生存期和生存质量的影响。方法选取本院2015年1月至2016年4月收治的局部晚期宫颈癌患者106例为研究对象,根据随机数表法将入选患者分为观察组(53例)和对照组(53例),观察组患者采用组织间插植近距离治疗,对照组患者采用腔内近距离治疗,比较两组患者的临床疗效、肿瘤靶区覆盖率、局部控制率、生存期和生存质量。结果观察组患者放疗后有效率、肿瘤靶区覆盖率和局部控制率均显著高于对照组(均P<0.05),死亡率显著低于对照组(P<0.05);放疗后36个月,观察组患者生理状况、情感状况、功能状况评分和总分均显著高于对照组(均P<0.01)。结论与腔内近距离治疗相比,组织间插植近距离治疗能够显著提高局部晚期宫颈癌患者肿瘤靶区覆盖率、肿瘤局部控制率和生存质量,延长患者生存期。

Objective To investigate the effects of interstitial brachytherapy and interstitial brachytherapy on survival and quality of life in patients with locally advanced cervical cancer. Method 106 patients with locally advanced cervical cancer admitted in our hospital from January 2015 to April 2016 were selected as the study objects. According to the random number table, patients were divided into observation group (53 cases) and control group (53 cases). Patients in observation group were treated with interstitial brachytherapy. Patients in control group were treated with intracavitary brachytherapy. The clinical efficacy, tumor target coverage, local control rate, survival time and quality of life were compared between the two groups. Result The effective rate after radiotherapy, the tumor target coverage rate and local control rate in observation group were significantly higher than those in control group (all P < 0.05). The death rate in observation group was significantly lower than that in control group (all P < 0.05). After 36 months of radiotherapy, the physiological status, emotional status, functional status and total score of patients in observation group were significantly higher than those in control group (all P < 0.01). Conclusion Compared with intracavitary brachytherapy, the interstitial brachytherapy can signifcantly improve the locally advanced cervical cancer patients' tumor target coverage, local control rate and quality of life, and prolong the survival of patients.