摘要
目的:分析厄洛替尼对大鼠小肠上皮细胞跨膜转运的影响。方法:通过在体肠灌流及大鼠药动学实验,比较厄洛替尼给药组与对照组药动学参数的变化。结果:多次给予厄洛替尼后,大鼠的体重及摄食量显著下降,荧光素钠的小肠透过率增加,单次给予厄洛替尼有增加头孢克洛吸收的趋势。结论:厄洛替尼可通过增加细胞旁路通透性从而增加小肠上皮的吸收。
Objective: To study the effect of erotinib on transmembrane transport of intestinal epithelial cells in rats. Methods: The changes of pharmacokinetic parameters in erlotinib group and control group were compared by intestinal perfusion and pharmacokinetic experiments in rats. Results: After repeated erlotinib administration, the weight and food intake of the rats decreased significantly, and the intestinal transmittance of luciferin sodium increased. Single administration of erlotinib tends to increase cefaclor absorption. Conclusion: Erotinib can increase intestinal epithelial absorption by increasing paracellular permeability.
作者
刘治芳
朱艳妮
Liu Zhi-fang;Zhu Yan-Ni(Changsha Medical University, Changsha 410219)
出处
《生物化工》
2019年第5期27-29,共3页
Biological Chemical Engineering
基金
湖南省教育厅科研项目(项目编号:15C0160)
关键词
厄洛替尼
膜通透性
吸收
Erlotinib
Membrane permeability
Absorption
