地西泮联合苯巴比妥治疗小儿热性惊厥的效果分析

Effect analysis of diazepam combined with phenobarbital in the treatment of febrile convulsions in children

目的探讨地西泮联合苯巴比妥治疗小儿热性惊厥的临床效果。方法选择2015年1月至2017年7月宁波市妇女儿童医院收治的小儿热性惊厥患儿100例为研究对象,采用随机数字表法分为两组各50例,对照组给予地西泮治疗,观察组给予地西泮联合苯巴比妥治疗,比较两组患儿的临床疗效、止惊时间、心肌酶指标、超敏C反应蛋白、不良反应发生率。结果(1)观察组的临床总有效率(98%)高于对照组(χ2=4.891,P<0.05),其止惊时间[(20.92±4.49)min]短于对照组(t=5.443,P<0.05)。(2)两组治疗后,观察组的肌酸激酶同工酶[(25.93±12.76)U/L]、磷酸肌酸酶[(189.47±7.35)U/L]、羟丁酸脱氢酶[(276.73±12.85)U/L]、乳酸脱氢酶[(305.94±13.27)U/L]、超敏C反应蛋白[(5.04±1.65)ng/L]均低于对照组(t=4.961、5.333、5.901、6.160、5.354,均P<0.05)。(3)治疗期间,两组均未发生明显不良反应。结论地西泮联合苯巴比妥可有效促使热性惊厥患儿止惊,有利于提高患儿的临床疗效,保护其心肌细胞,且不良反应少,安全可靠。

Objective To investigate the clinical effect of diazepam combined with phenobarbital in the treatment of febrile convulsions in children. Methods From January 2015 to July 2017, 100 children with febrile convulsions in the Women's and Children's Hospital of Ningbo were selected and divided into two groups by random number table, with 50 cases in each group.The control group was treated with diazepam, while the observation group was treated with diazepam combined with phenobarbital.The clinical efficacy, anticonvulsive time, myocardial enzyme index, hypersensitive C-reactive protein and incidence of adverse reactions were compared between the two groups. Results(1)The total clinical effective rate of the observation group(98%) was higher than that of the control group(χ2=4.891, P<0.05), and the time of stopping convulsion[(20.92±4.49)min] was shorter than that of the control group(t=5.443, P<0.05).(2)After treatment, the creatine kinase isoenzymes[(25.93±12.76)U/L], phosphocreatinase[(189.47±7.35)U/L], hydroxybutyrate dehydrogenase[(276.73±12.85)U/L], lactate dehydrogenase[(305.94±13.27)U/L], hypersensitive C-reactive protein[(5.04±1.65)ng/L] in the observation group were lower than those in the control group(t=4.961, 5.333, 5.901, 6.160, 5.354, all P<0.05).(3)During the treatment period, no obvious adverse reactions occurred in both two groups. Conclusion The combination of diazepam and phenobarbital can effectively arrest febrile convulsions in children, improve the clinical efficacy, protect myocardial cells, it has fewer adverse reactions, it is safe and reliable.