支气管哮喘患儿感染肺炎支原体后抗体滴度与免疫平衡的相关性分析

Correlation analysis of antibody titer and immune balance after infection of mycoplasma pneumoniae in children with bronchial asthma

目的探讨支气管哮喘患儿感染肺炎支原体后抗体滴度与免疫平衡的相关性。方法选择2010年10月至2015年8月在齐河县妇幼保健院就诊的支气管哮喘感染肺炎支原体患儿108例为研究对象,71例患儿作为观察组,患儿肺炎支原体抗体滴度>1∶160;37例患儿作为对照组,肺炎支原体抗体滴度≤1∶160。测定患儿血清干扰素-γ(IFN-γ)、白细胞介素4(IL-4)、白细胞介素17(IL-17)。结果对照组患儿血清IFN-γ、IL-4、IL-17分别为(41.04±3.13)μg/L、(17.04±3.16)μg/L、(30.81±4.23)μg/L,观察组患儿血清IFN-γ、IL-4、IL-17分别为(33.26±3.17)μg/L、(24.15±5.09)μg/L、(41.29±5.09)μg/L,观察组患儿感染肺炎支原体后血清IL-4、IL-17明显高于对照组(t=5.126、3.429,均P<0.05);感染肺炎支原体后,观察组患儿血清IFN-γ明显降低对照组(t=4.168,P<0.05)。结论支气管哮喘患儿感染肺炎支原体后抗体滴度与免疫平衡有密切的关系,抗体滴度越高,免疫失衡越严重。

Objective To study the correlation of antibody titer and immune balance after infection of mycoplasma pneumoniae in children with bronchial asthma. Methods From October 2010 to August 2015, 108 children with bronchial asthma infected with mycoplasma pneumoniae were selected.There were 71 patients in the observation group, children with mycoplasma pneumoniae antibody titers >1∶160, and 37 cases were selected as control group, mycoplasma pneumonia antibody titer≤1∶160.The titer of mycoplasma antibody, serum interferon gamma(IFN-γ), interleukin-4(IL-4) and interleukin-17(IL-17) were measured. Results The serum IFN-γ, IL-4 and IL-17 levels in the control group were (41.04±3.13)μg/L,(17.04±3.16)μg/L and (30.81±4.23)μg/L, respectively, which in the observation group were (33.26±3.17)μg/L,(24.15±5.09)μg/L and (41.29±5.09)μg/L, respectively.The serum IL-4 and IL-17 levels of the observation group were significantly higher than those of the control group(t=5.126, 3.429, all P<0.05). After infection of mycoplasma pneumoniae, the serum IFN-γ in the observation group decreased significantly(t=4.168, P<0.05). Conclusion The titer of antibody after mycoplasma pneumoniae infection in children with bronchial asthma is closely related to the immune balance.The higher the antibody titer, the more serious the immune imbalance.