抗菌药物序贯疗法治疗儿童细菌感染性急性肠系膜淋巴结炎的效果观察

Effect of sequential therapy of antibacterial drugs on acute mesenteric lymphadenitis caused by bacterial infection in children

目的探讨细菌感染致儿童急性肠系膜淋巴结炎采用头孢类药物序贯疗法治疗疗效。方法随机选取2015年12月至2018年12月绍兴市中心医院细菌感染致儿童急性肠系膜淋巴结炎患者66例为研究对象,其中静脉滴注头孢呋辛者为对照组(33例);另33例为观察组,采用静脉滴注头孢呋辛,待患儿腹痛消失且外周血细胞计数等恢复正常后,再给予头孢呋辛酯片口服治疗。评价两组临床疗效,统计两组治疗费用及不良反应。结果观察组治疗总有效率96.97%(32/33),与对照组的90.91%(30/33)相比较,差异无统计学意义(χ2=1.26,P=0.53);观察组治疗总费用(326.85±51.88)元,较对照组的(576.82±72.17)元低,差异有统计学意义(t=16.15,P=0.00)。两组治疗期间无明显不良反应。结论头孢呋辛序贯疗法与单纯静脉滴注头孢呋辛治疗细菌感染致儿童急性肠系膜淋巴结炎疗效相当且具有较高安全性,但序贯疗法费用更低,因此值得推荐。

Objective To investigate the effect of cephalosporin sequential therapy on acute mesenteric lymphadenitis caused by bacterial infection. Methods From December 2015 to December 2018, 66 patients with acute mesenteric lymphadenitis caused by bacterial infection in Shaoxing Central Hospital were randomly selected.The control group(33 cases) received intravenous infusion of cefuroxime.The observation group(33 cases) was treated with intravenous infusion of cefuroxime, after the abdominal pain disappeared and the peripheral blood cell count returned to normal, the cefuroxime axetil tablet was given orally.The clinical efficacy of the two groups was evaluated, and the treatment costs and adverse reactions of the two groups were counted. Results The total effective rate of the observation group was 96.97%(32/33), compared with 90.91%(30/33) of the control group, the difference was not statistically significant(χ2=1.26, P=0.53). The total cost of treatment in the observation group was (326.85±51.88)CNY, which was lower than that of the control group[(576.82±72.17)CNY], the difference was statistically significant(t=16.15, P=0.00). There were no significant adverse reactions in the two groups during treatment periods. Conclusion Sequential therapy with cefuroxime and venous infusion of cefuroxime for the treatment of acute mesenteric lymphadenitis in children with bacterial infection is safe, but sequential therapy is less expensive and therefore recommended.