摘要
A central objective in deciphering the nervous system in health and disease is to define the connections of neurons. The propensity of neurotropic viruses to spread among synaptically-linked neurons makes them ideal for mapping neural circuits. So far, several classes of viral neuronal tracers have become available and provide a powerful toolbox for delineating neural networks. In this paper, we review the recent developments of neurotropic viral tracers and highlight their unique properties in revealing patterns of neuronal connections.
A central objective in deciphering the nervous system in health and disease is to define the connections of neurons. The propensity of neurotropic viruses to spread among synaptically-linked neurons makes them ideal for mapping neural circuits. So far, several classes of viral neuronal tracers have become available and provide a powerful toolbox for delineating neural networks. In this paper, we review the recent developments of neurotropic viral tracers and highlight their unique properties in revealing patterns of neuronal connections.
基金
supported by the National Natural Science Foundation of China (31671119 and 31871090)
the Shenzhen Science and Technology Innovation Commission (JCYJ20160428164440255, JCYJ20170413162938668, JCYJ20170818155056369, and JCYJ20170307170742519)
the Shenzhen Discipline Construction Project for Neurobiology (DRCSM [2016]1379)
the Japan Society for the Promotion of Science KAKENHI (JP18K08494)
the Japan Science and Technology Agency PRESTO (JPMJPR1784)
the Ono Medical Research Foundation, and the Novartis Foundation (Japan) for the Promotion of Science
