摘要
血红素加氧酶-1(HO-1)是机体内广泛存在的抗氧化防御酶。在正常生理状态下,HO-1的表达水平较低。在缺血、缺氧、炎症等多种应激状态下,HO-1可被诱导大量表达,进而在多种疾病中发挥细胞保护作用。但对于HO-1与感染性疾病的相关研究报道较少。现对HO-1在感染性疾病(细菌、真菌、寄生虫、病毒)中的作用进行综述。
Heme oxygenase-1 (HO-1) is a kind of antioxidant defense enzymes,which widely exists in the body.Under normal physiological condition,the expression level of HO-1 is low.HO-1 can be induced to express in large quantities under various stress states,thus plays the cellular protective effect in various diseases.The relevant research reports of HO-1 and infectious diseases are less.This paper reviews the role of HO-1 in infectious diseases (bacteria,fungi,parasites,viruses).
作者
王凡
王宏娟
徐世明
WANG Fan;WANG Hongjuan;XU Shiming(Teaching and Researching Section of Biochemistry and Molucular Biology,Yanjing Medical College,Capital Medical University,Beijing 101300,China)
出处
《重庆医学》
CAS
2019年第20期3541-3544,共4页
Chongqing medicine
基金
北京市自然科学基金项目(7132033)
燕京医学院科研基金项目(19py01
18qdky04
19qdky01)
