右雷佐生联合榄香烯降低蒽环类药物心脏毒性疗效观察

Clinical Observation on Dexrazoxane Combined with Elemene in Reducing the Cardiotoxicity Induced by Anthracycline Drugs

目的探讨右雷佐生联合榄香烯注射液降低蒽环类药物心脏毒性的临床疗效。方法选取医院2013年6月至2017年10月应用蒽环类药物治疗的癌症患者58例,分为单药组(31例)和联用组(27例)。单药组在应用蒽环类药物基础上加用右雷佐生静脉滴注,联用组在单药组基础上联合榄香烯注射液。结果联用组主动脉增宽和心包积液等心脏毒性的发生率低于单药组(P <0. 05)。结论右雷佐生联合榄香烯注射液可有效减轻蒽环类药物对癌症患者的心脏毒性作用。

Objective To investigate the clinical efficacy of dexrazoxane combined with Elemene Injection in reducing the cardiotoxicity induced by anthracycline drugs. Methods Totally 58 patients with cancer treated with anthracycline drugs in our hospital from June2013 to October 2017 were selected and divided into the single-drug group( n = 31) and the combination group( n = 27). The patients in the single-drug group were given intravenous drip of dexrazoxane on the basis of anthracycline drugs,while those in the combination group were treated with Elemene Injection on the basis of the single-drug group. Results The incidence of cardiotoxicity such as aortic widening and pericardial effusion in the combination group was lower than that in the single-drug group( P < 0. 05). Conclusion Dexrazoxane combined with Elemene Injection can effectively reduce the cardiotoxicity of patients with cancer treated with anthracycline drugs.