黄连紫草膏对小面积深二度烧伤创面愈合的治疗效果

Treatment effect of Huanglian Zicao Ointment on wound healing of small area deep partial thickness burn wound

目的观察黄连紫草膏对小面积深二度烧伤创面愈合的治疗效果。方法收集2018年1~7月我院烧伤科收治的深二度烧伤成年患者60例,深二度烧伤面积为1%~3%TBSA。按随机数字表法将患者分为黄连紫草膏治疗组(观察组)和银离子抗菌凝胶治疗组(对照组),每组30例。创面清创后,观察组用黄连紫草膏涂抹,油纱覆盖包扎,对照组用银离子抗菌凝胶涂抹,银离子敷料覆盖包扎,每日换药1次。观察两组患者创面愈合时间,第21、28天创面愈合率;分别在第1、4、7、14、21天进行换药时视觉模拟评分(VAS)、创面细菌培养;记录创面过敏反应等指标。结果观察组创面愈合时间短于对照组,第21、28天创面愈合率高于对照组,差异有统计学意义(P<0.05)。除第1天外,之后观察组的VAS评分均低于对照组,差异有统计学意义(P<0.05)。不同时间点的创面细菌培养,两组间差异无统计学意义(P>0.05)。观察组3例、对照组2例出现轻微创面过敏反应,无其它明显不良反应。结论对比银离子抗菌凝胶,黄连紫草膏更有利于小面积深二度烧伤的治疗,明显减轻换药时的疼痛,促进创面愈合。

Objective To observe the clinical effect of Huanglian Zicao Ointment on wound healing of small area deep partial thickness burn wound. Methods From Jan to Jul in 2018, sixty adult patients with deep partial thickness burn wound were enrolled in the burn department of our hospital. The area of deep partial thickness burn wound was 1%~3% of TBSA. The patients were randomly divided into Huanglian Zicao Ointment group (observation group) and silver ion antibacterial gel group (control group), with 30 cases in each group. After debridement, the observation group was smeared with Huanglian Zicao Ointment and coated with oil sand, while the control group was smeared with silver ion antibacterial gel and coated with silver ion dressing, changed medicine once a day. The wound healing time, wound healing rate on the 21th and 28th day were observed, the visual analogue score (VAS) and bacterial culture were conducted on the first, 4th, 7th, 14th and 21th day after treatment, and wound anaphylaxis were observed. Results The wound healing time in the observation group was lower than that in the control group, the healing rate on the 21th day and the 28th day were higher than that in the control group (P< 0.05). Except the VAS score on the first day, the later VAS score in the observation group were lower than that in the control group with statistical significance (P< 0.05). There was no significant difference in bacterial culture between the two groups at different time points (P> 0. 05). Mild wound anaphylaxis occured on 3 cases in the observation group and 2 cases in the control group. Conclusion Compared with silver ion antibacterial gel, Huanglian Zicao Ointment is more beneficial to the treatment of small area deep partial thickness burn wound, obviously relieve pain during dressing change, promote wound healing.