脊柱外科手术中氨甲环酸的应用

Application of tranexamic acid in spinal surgery

随着科学技术的不断进步,脊柱这一曾经的手术禁区,目前已取得较好的手术疗效,例如上颈椎(寰枢椎)、先天性脊柱侧弯、脊柱结核及肿瘤等复杂手术。尽管如此,在脊柱手术过程中仍因为手术节段多、剥离组织肌肉多,导致术区出血量较大,影响手术效果。氨甲环酸是一种纤溶酶抑制剂,通过竞争性抑制纤溶酶原激活因子,从而阻断纤溶酶原激活为纤溶酶起到抗纤溶的作用。现广泛应用于普外科、胸外科及妇产科等,本文就氨甲环酸应用于脊柱外科研究进展作一综述。

With the continuous advancement of science and technology,the spine,a former surgical exclusion zone,has achieved good surgical outcomes,such as the upper cervical spine(axial atlanto),congenital scoliosis,spinal tuberculosis and tumors.However,during the spinal surgery,because of the large number of surgical segments and the removal of tissue muscles,the amount of bleeding in the operation area is large,which affects the surgical results.Tranexamic acid is a plasmin inhibitor that inhibits the activation of plasminogen to act on plasmin to prevent fibrinolysis by competitively inhibiting plasminogen activator.It is widely used in general surgery,thoracic surgery and obstetrics and gynecology.The following is a summary of the research progress of tranexamic acid in spinal surgery.