幽门螺杆菌感染对儿童过敏性紫癜预后的影响

Effect of Helicobacter pylori infection on prognosis of children with Henoch-Schonlein purpura

目的探究幽门螺杆菌感染(Hp)对儿童过敏性紫癜(HSP)预后的影响。方法选择近年我院收治的156例HSP患儿,按是否伴有Hp感染及治疗方案不同,分为非Hp感染组91例、Hp感染常规治疗组32例、Hp感染抗Hp治疗组33例,对于HSP患儿三组均予以常规治疗,其中抗Hp治疗组加用根除Hp三联疗法治疗,对比三组临床疗效及复发率。结果三组临床总有效率分别为87.91%、84.38%、84.84%,三组比较差异无统计学意义(P>0.05)。随访6个月,常规治疗组复发率为25.00%,高于非Hp感染组的8.79%、抗Hp治疗组的6.06%。结论Hp感染的过敏性紫癜患儿预后较差,复发率较高。

Objective To explore the effect of Helicobacter pylori infection on prognosis of children with Henoch-Schonlein purpura.Methods A total of 156 children with HSP admitted to our hospital in recent years were divided into a non-Hp infection group(n=91),a conventional treatment for Hp infection group(n=32)and an anti-Hp treatment for Hp infection group(n=33)according to whether they had the Hp infection and different treatment regimens.All the children with HSP in three groups received conventional treatment,among which anti-Hp treatment group was treated with triple therapy to eradicate Hp in addition.The clinical efficacy and recurrence rate of the three groups were compared.Results The total clinical effective rates of the three groups were 87.91%,84.38%and 84.84%respectively,there was no statistically significant difference among the three groups(P>0.05).The 6-month follow-up showed that the recurrence rate in the conventional treatment group was 25.00%,higher than that in the non-Hp infection group(8.79%)and the anti-Hp treatment group(6.06%)(P<0.05).Conclusion HSP children with Hp infection have a poorer prognosis and a higher recurrence rate.